BRD-A28970875_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

156 genes differentially expressed following the BRD-A28970875_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARID4B AT rich interactive domain 4B (RBP1-like)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BTG1 B-cell translocation gene 1, anti-proliferative
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CLU clusterin
CSRP2 cysteine and glycine-rich protein 2
CTH cystathionine gamma-lyase
CXCL8 chemokine (C-X-C motif) ligand 8
DAAM1 dishevelled associated activator of morphogenesis 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EIF1 eukaryotic translation initiation factor 1
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
FAM129A family with sequence similarity 129, member A
FOXO3 forkhead box O3
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
H3F3B H3 histone, family 3B (H3.3B)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLK6 kallikrein-related peptidase 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP7 microtubule-associated protein 7
MARS methionyl-tRNA synthetase
MED13 mediator complex subunit 13
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
OSER1 oxidative stress responsive serine-rich 1
P3H2 prolyl 3-hydroxylase 2
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAWR PRKC, apoptosis, WT1, regulator
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTPRO protein tyrosine phosphatase, receptor type, O
QPCT glutaminyl-peptide cyclotransferase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
RSRC2 arginine/serine-rich coiled-coil 2
SIK1 salt-inducible kinase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC38A2 solute carrier family 38, member 2
SYNGR3 synaptogyrin 3
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
TES testin LIM domain protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
WAC WW domain containing adaptor with coiled-coil
WARS tryptophanyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZCCHC8 zinc finger, CCHC domain containing 8
ZFAND5 zinc finger, AN1-type domain 5
ZNF140 zinc finger protein 140
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ATF5 activating transcription factor 5
B3GNT1
BCHE butyrylcholinesterase
BST2 bone marrow stromal cell antigen 2
CCNG1 cyclin G1
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CES1 carboxylesterase 1
CFI complement factor I
CNPY2 canopy FGF signaling regulator 2
DHRS1 dehydrogenase/reductase (SDR family) member 1
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENDOD1 endonuclease domain containing 1
EPCAM epithelial cell adhesion molecule
ESR1 estrogen receptor 1
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLM1 golgi membrane protein 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI30 interferon, gamma-inducible protein 30
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
KIAA0101 KIAA0101
KIAA0907 KIAA0907
KRT5 keratin 5, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MRPL19 mitochondrial ribosomal protein L19
NQO1 NAD(P)H dehydrogenase, quinone 1
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
PDGFA platelet-derived growth factor alpha polypeptide
PRSS23 protease, serine, 23
PSRC1 proline/serine-rich coiled-coil 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SORD sorbitol dehydrogenase
SRPX sushi-repeat containing protein, X-linked
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACSTD2 tumor-associated calcium signal transducer 2
TFDP1 transcription factor Dp-1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TSPAN13 tetraspanin 13
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)