BRD-A28105619_curcubitacin I_THP1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

235 genes differentially expressed following the BRD-A28105619_curcubitacin I_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTG2 actin, gamma 2, smooth muscle, enteric
ADM adrenomedullin
AKAP13 A kinase (PRKA) anchor protein 13
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL3 B-cell CLL/lymphoma 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CARS cysteinyl-tRNA synthetase
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CENPE centromere protein E, 312kDa
CHIC2 cysteine-rich hydrophobic domain 2
CLEC2B C-type lectin domain family 2, member B
CRYAB crystallin, alpha B
CSRNP2 cysteine-serine-rich nuclear protein 2
CTH cystathionine gamma-lyase
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
FLOT1 flotillin 1
FOXO3 forkhead box O3
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FXR1 fragile X mental retardation, autosomal homolog 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GPM6B glycoprotein M6B
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
ITGA6 integrin, alpha 6
JUN jun proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KLHL24 kelch-like family member 24
LAMP3 lysosomal-associated membrane protein 3
LRP10 low density lipoprotein receptor-related protein 10
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARS methionyl-tRNA synthetase
MATN2 matrilin 2
MEF2C myocyte enhancer factor 2C
MICALL1 MICAL-like 1
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1M metallothionein 1M
MYL9 myosin, light chain 9, regulatory
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NMRK1 nicotinamide riboside kinase 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
P3H2 prolyl 3-hydroxylase 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHIP pleckstrin homology domain interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLA2G16 phospholipase A2, group XVI
PLIN2 perilipin 2
PLS3 plastin 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRRC2C proline-rich coiled-coil 2C
PSAT1 phosphoserine aminotransferase 1
RAB9A RAB9A, member RAS oncogene family
RIOK3 RIO kinase 3
RTN2 reticulon 2
RYBP RING1 and YY1 binding protein
S100A13 S100 calcium binding protein A13
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TES testin LIM domain protein
TESK1 testis-specific kinase 1
TFE3 transcription factor binding to IGHM enhancer 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TMSB15A thymosin beta 15a
TPM2 tropomyosin 2 (beta)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AKAP1 A kinase (PRKA) anchor protein 1
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANAPC13 anaphase promoting complex subunit 13
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C3 complement component 3
CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
CALR calreticulin
CCDC86 coiled-coil domain containing 86
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CP ceruloplasmin (ferroxidase)
CRISP3 cysteine-rich secretory protein 3
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
DCTPP1 dCTP pyrophosphatase 1
DEFB1 defensin, beta 1
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DPH2 DPH2 homolog (S. cerevisiae)
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ERLIN1 ER lipid raft associated 1
ESR1 estrogen receptor 1
EXOSC4 exosome component 4
FEN1 flap structure-specific endonuclease 1
FKBP1A FK506 binding protein 1A, 12kDa
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
INSIG1 insulin induced gene 1
IPO5 importin 5
IRS2 insulin receptor substrate 2
KANK1 KN motif and ankyrin repeat domains 1
KARS lysyl-tRNA synthetase
KCTD12 potassium channel tetramerization domain containing 12
KIAA0100 KIAA0100
LEF1 lymphoid enhancer-binding factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAT2A methionine adenosyltransferase II, alpha
MLEC malectin
MRPL12 mitochondrial ribosomal protein L12
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT10 N-acetyltransferase 10 (GCN5-related)
NDN necdin, melanoma antigen (MAGE) family member
NHP2 NHP2 ribonucleoprotein
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
NIP7 NIP7, nucleolar pre-rRNA processing protein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NT5DC2 5'-nucleotidase domain containing 2
NXT1 nuclear transport factor 2-like export factor 1
PA2G4 proliferation-associated 2G4, 38kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1
PEG3 paternally expressed 3
PHB prohibitin
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR1C polymerase (RNA) I polypeptide C, 30kDa
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PRKCD protein kinase C, delta
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTRH2 peptidyl-tRNA hydrolase 2
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RPIA ribose 5-phosphate isomerase A
RRP1B ribosomal RNA processing 1B
RUVBL1 RuvB-like AAA ATPase 1
SEH1L SEH1-like (S. cerevisiae)
SERBP1 SERPINE1 mRNA binding protein 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32
SLC43A3 solute carrier family 43, member 3
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
SRM spermidine synthase
SRPRB signal recognition particle receptor, B subunit
SRSF1 serine/arginine-rich splicing factor 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCL1A T-cell leukemia/lymphoma 1A
TFAM transcription factor A, mitochondrial
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2N ubiquitin-conjugating enzyme E2N
UQCRH ubiquinol-cytochrome c reductase hinge protein
VNN1 vanin 1
WDR3 WD repeat domain 3
WDR77 WD repeat domain 77