BRD-A28105619_curcubitacin I_SNGM_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

238 genes differentially expressed following the BRD-A28105619_curcubitacin I_SNGM_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANPEP alanyl (membrane) aminopeptidase
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATG3 autophagy related 3
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
C21ORF91 chromosome 21 open reading frame 91
CCNL1 cyclin L1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLGN calmegin
CRISP3 cysteine-rich secretory protein 3
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFA4 defensin, alpha 4, corticostatin
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FAM46A family with sequence similarity 46, member A
FAM53C family with sequence similarity 53, member C
FHL2 four and a half LIM domains 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GATA2 GATA binding protein 2
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LOC81691 exonuclease NEF-sp
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MSRA methionine sulfoxide reductase A
NDC80 NDC80 kinetochore complex component
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PARP2 poly (ADP-ribose) polymerase 2
PCDH9 protocadherin 9
PHYH phytanoyl-CoA 2-hydroxylase
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTBP2 polypyrimidine tract binding protein 2
RAD23B RAD23 homolog B (S. cerevisiae)
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
RPP38 ribonuclease P/MRP 38kDa subunit
RSRC2 arginine/serine-rich coiled-coil 2
S100A12 S100 calcium binding protein A12
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SQSTM1 sequestosome 1
SRSF7 serine/arginine-rich splicing factor 7
SSX1 synovial sarcoma, X breakpoint 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TARS threonyl-tRNA synthetase
TBX3 T-box 3
TEX10 testis expressed 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOMM34 translocase of outer mitochondrial membrane 34
TREM1 triggering receptor expressed on myeloid cells 1
TRIM24 tripartite motif containing 24
UBAP2 ubiquitin associated protein 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2S ubiquitin-conjugating enzyme E2S
UPP1 uridine phosphorylase 1
WAC WW domain containing adaptor with coiled-coil
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274
ZNF451 zinc finger protein 451
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIM1 absent in melanoma 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
ARMCX2 armadillo repeat containing, X-linked 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
C3 complement component 3
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCL2 chemokine (C-C motif) ligand 2
CCND1 cyclin D1
CCND2 cyclin D2
CD24 CD24 molecule
CD99 CD99 molecule
CDK2 cyclin-dependent kinase 2
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLDN3 claudin 3
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCR4 chemokine (C-X-C motif) receptor 4
CYB5A cytochrome b5 type A (microsomal)
DCK deoxycytidine kinase
DKK4 dickkopf WNT signaling pathway inhibitor 4
DPYSL2 dihydropyrimidinase-like 2
EDN1 endothelin 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
ERLIN2 ER lipid raft associated 2
EZR ezrin
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FBN2 fibrillin 2
FGFR2 fibroblast growth factor receptor 2
FKBP11 FK506 binding protein 11, 19 kDa
FKBP1A FK506 binding protein 1A, 12kDa
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FST follistatin
FSTL1 follistatin-like 1
GJA1 gap junction protein, alpha 1, 43kDa
GPX1 glutathione peroxidase 1
HBB hemoglobin, beta
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEATR1 HEAT repeat containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGA2 high mobility group AT-hook 2
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LOXL2 lysyl oxidase-like 2
LRP4 low density lipoprotein receptor-related protein 4
LSR lipolysis stimulated lipoprotein receptor
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MMP7 matrix metallopeptidase 7
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NEBL nebulette
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NNMT nicotinamide N-methyltransferase
NPTN neuroplastin
OLFML2A olfactomedin-like 2A
OPN3 opsin 3
PALLD palladin, cytoskeletal associated protein
PARP1 poly (ADP-ribose) polymerase 1
PBX1 pre-B-cell leukemia homeobox 1
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMA2 paraneoplastic Ma antigen 2
POSTN periostin, osteoblast specific factor
PTMA prothymosin, alpha
PTPRE protein tyrosine phosphatase, receptor type, E
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCAN2 regulator of calcineurin 2
RIN2 Ras and Rab interactor 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF43 ring finger protein 43
SACS sacsin molecular chaperone
SCAMP1 secretory carrier membrane protein 1
SCARB2 scavenger receptor class B, member 2
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIRPA signal-regulatory protein alpha
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SNN stannin
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SPP1 secreted phosphoprotein 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRGN serglycin
TAGLN transgelin
TCF4 transcription factor 4
TFRC transferrin receptor
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPD52L1 tumor protein D52-like 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIL TLR4 interactor with leucine-rich repeats
TRIM2 tripartite motif containing 2
TSPAN12 tetraspanin 12
TSPAN5 tetraspanin 5
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VGLL4 vestigial-like family member 4
XIST X inactive specific transcript (non-protein coding)