BRD-A28105619_curcubitacin I_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

135 genes differentially expressed following the BRD-A28105619_curcubitacin I_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ACTN1 actinin, alpha 1
ADM adrenomedullin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CRABP1 cellular retinoic acid binding protein 1
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GREB1 growth regulation by estrogen in breast cancer 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER2 immediate early response 2
IFRD1 interferon-related developmental regulator 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
KCMF1 potassium channel modulatory factor 1
KDM3A lysine (K)-specific demethylase 3A
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MT1G metallothionein 1G
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYL9 myosin, light chain 9, regulatory
NAV3 neuron navigator 3
PARP2 poly (ADP-ribose) polymerase 2
PELI1 pellino E3 ubiquitin protein ligase 1
PTX3 pentraxin 3, long
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RND3 Rho family GTPase 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX11 sorting nexin 11
SPAG9 sperm associated antigen 9
SPRED2 sprouty-related, EVH1 domain containing 2
SRGN serglycin
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
WIF1 WNT inhibitory factor 1
YARS tyrosyl-tRNA synthetase
ZFP36 ZFP36 ring finger protein
ZNF93 zinc finger protein 93

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHCY adenosylhomocysteinase
AHSG alpha-2-HS-glycoprotein
AIM1 absent in melanoma 1
ATF5 activating transcription factor 5
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
B3GNT1
BLNK B-cell linker
CANT1 calcium activated nucleotidase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CFH complement factor H
CFI complement factor I
COL1A2 collagen, type I, alpha 2
DHCR24 24-dehydrocholesterol reductase
ERLIN2 ER lipid raft associated 2
FABP1 fatty acid binding protein 1, liver
FAM69A family with sequence similarity 69, member A
GLUL glutamate-ammonia ligase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IL17RB interleukin 17 receptor B
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KNG1 kininogen 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MXRA5 matrix-remodelling associated 5
ORM1 orosomucoid 1
PCNA proliferating cell nuclear antigen
PDHB pyruvate dehydrogenase (lipoamide) beta
PTPRC protein tyrosine phosphatase, receptor type, C
RBP4 retinol binding protein 4, plasma
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SORBS3 sorbin and SH3 domain containing 3
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFPI2 tissue factor pathway inhibitor 2
TYMS thymidylate synthetase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon