BRD-A26711594_NICARDIPINE HYDROCHLORIDE_EFO27_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

151 genes differentially expressed following the BRD-A26711594_NICARDIPINE HYDROCHLORIDE_EFO27_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
BAG2 BCL2-associated athanogene 2
BASP1 brain abundant, membrane attached signal protein 1
CASP7 caspase 7, apoptosis-related cysteine peptidase
CD59 CD59 molecule, complement regulatory protein
CDC14B cell division cycle 14B
CHL1 cell adhesion molecule L1-like
CHPT1 choline phosphotransferase 1
CLDN10 claudin 10
CPD carboxypeptidase D
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP2 cysteine and glycine-rich protein 2
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYCS cytochrome c, somatic
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMD dystrophin
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EREG epiregulin
ETNPPL ethanolamine-phosphate phospho-lyase
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM171A1 family with sequence similarity 171, member A1
FOXC1 forkhead box C1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GOLM1 golgi membrane protein 1
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GRAMD3 GRAM domain containing 3
HDGFRP3 hepatoma-derived growth factor, related protein 3
HOMER2 homer scaffolding protein 2
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL6ST interleukin 6 signal transducer
IQCG IQ motif containing G
IQGAP1 IQ motif containing GTPase activating protein 1
JARID2 jumonji, AT rich interactive domain 2
KIF1B kinesin family member 1B
KIF5C kinesin family member 5C
KLF2 Kruppel-like factor 2
KRT10 keratin 10, type I
LEPR leptin receptor
LTF lactotransferrin
LYPLA1 lysophospholipase I
MPP1 membrane protein, palmitoylated 1, 55kDa
MSX1 msh homeobox 1
NAMPT nicotinamide phosphoribosyltransferase
NPC2 Niemann-Pick disease, type C2
ODAM odontogenic, ameloblast asssociated
OLFM1 olfactomedin 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLS3 plastin 3
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PSIP1 PC4 and SFRS1 interacting protein 1
PTER phosphotriesterase related
PTGES prostaglandin E synthase
RUNX3 runt-related transcription factor 3
SATB2 SATB homeobox 2
SCRN1 secernin 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP1 S-phase kinase-associated protein 1
SLC25A46 solute carrier family 25, member 46
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF1 serine/arginine-rich splicing factor 1
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TLR4 toll-like receptor 4
TNC tenascin C
WAC WW domain containing adaptor with coiled-coil
ZEB2 zinc finger E-box binding homeobox 2

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPN asporin
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CCR2 chemokine (C-C motif) receptor 2
CD1E CD1e molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD93 CD93 molecule
CHGB chromogranin B
CLDN3 claudin 3
CLIC4 chloride intracellular channel 4
CNPY3 canopy FGF signaling regulator 3
COL10A1 collagen, type X, alpha 1
CPE carboxypeptidase E
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DENND1B DENN/MADD domain containing 1B
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPHA3 EPH receptor A3
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FGL2 fibrinogen-like 2
FILIP1L filamin A interacting protein 1-like
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
IFNAR1 interferon (alpha, beta and omega) receptor 1
KCNK3 potassium channel, two pore domain subfamily K, member 3
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
LRRC41 leucine rich repeat containing 41
LYZ lysozyme
MEST mesoderm specific transcript
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
NOX4 NADPH oxidase 4
OSBPL10 oxysterol binding protein-like 10
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PCSK1 proprotein convertase subtilisin/kexin type 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLN phospholamban
PMM2 phosphomannomutase 2
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SPON2 spondin 2, extracellular matrix protein
TAGLN transgelin
TESK1 testis-specific kinase 1
TMEM204 transmembrane protein 204
ZFPM2 zinc finger protein, FOG family member 2
ZNF652 zinc finger protein 652