BRD-A26002865_V4877_SKB_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

322 genes differentially expressed following the BRD-A26002865_V4877_SKB_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACKR3 atypical chemokine receptor 3
ADCK3 aarF domain containing kinase 3
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
AMDHD2 amidohydrolase domain containing 2
AQP1 aquaporin 1 (Colton blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARID5B AT rich interactive domain 5B (MRF1-like)
ARL4A ADP-ribosylation factor-like 4A
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BCL2 B-cell CLL/lymphoma 2
BEX1 brain expressed, X-linked 1
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
BRD2 bromodomain containing 2
BTG2 BTG family, member 2
C2CD5 C2 calcium-dependent domain containing 5
CCNL1 cyclin L1
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CD83 CD83 molecule
CDC25A cell division cycle 25A
CDKN2AIP CDKN2A interacting protein
CFLAR CASP8 and FADD-like apoptosis regulator
CHD1 chromodomain helicase DNA binding protein 1
CLK4 CDC-like kinase 4
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CRY1 cryptochrome circadian clock 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DLX2 distal-less homeobox 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EFNB2 ephrin-B2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETNK1 ethanolamine kinase 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GATA2 GATA binding protein 2
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GPATCH8 G patch domain containing 8
GPRASP1 G protein-coupled receptor associated sorting protein 1
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST2H2BE histone cluster 2, H2be
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HMGN3 high mobility group nucleosomal binding domain 3
HMOX1 heme oxygenase 1
HSPA4L heat shock 70kDa protein 4-like
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFIH1 interferon induced with helicase C domain 1
IFRD1 interferon-related developmental regulator 1
ING3 inhibitor of growth family, member 3
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUNB jun B proto-oncogene
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0907 KIAA0907
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MED13 mediator complex subunit 13
MED13L mediator complex subunit 13-like
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NOVA1 neuro-oncological ventral antigen 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
PARP6 poly (ADP-ribose) polymerase family, member 6
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PER2 period circadian clock 2
PER3 period circadian clock 3
PHIP pleckstrin homology domain interacting protein
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PNISR PNN-interacting serine/arginine-rich protein
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDM2 PR domain containing 2, with ZNF domain
PRKCH protein kinase C, eta
PRRC2C proline-rich coiled-coil 2C
PTGES prostaglandin E synthase
QKI QKI, KH domain containing, RNA binding
RAB2A RAB2A, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RIOK3 RIO kinase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAGC Ras-related GTP binding C
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
SELE selectin E
SELL selectin L
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERTAD2 SERTA domain containing 2
SFRP4 secreted frizzled-related protein 4
SIK3 SIK family kinase 3
SIRT1 sirtuin 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TEX10 testis expressed 10
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOMM34 translocase of outer mitochondrial membrane 34
TP53BP2 tumor protein p53 binding protein 2
TPST1 tyrosylprotein sulfotransferase 1
TRBC1 T cell receptor beta constant 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2H ubiquitin-conjugating enzyme E2H
UGCG UDP-glucose ceramide glucosyltransferase
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
YTHDC1 YTH domain containing 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB20 zinc finger and BTB domain containing 20
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF292 zinc finger protein 292
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM9 ADAM metallopeptidase domain 9
AIDA axin interactor, dorsalization associated
ANXA4 annexin A4
APMAP adipocyte plasma membrane associated protein
APOC1 apolipoprotein C-I
APOE apolipoprotein E
ASPH aspartate beta-hydroxylase
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCHE butyrylcholinesterase
BLCAP bladder cancer associated protein
BLVRA biliverdin reductase A
C1GALT1C1 C1GALT1-specific chaperone 1
CALU calumenin
CCND1 cyclin D1
CLNS1A chloride channel, nucleotide-sensitive, 1A
COL1A2 collagen, type I, alpha 2
COL4A1 collagen, type IV, alpha 1
COMT catechol-O-methyltransferase
CPM carboxypeptidase M
CREG1 cellular repressor of E1A-stimulated genes 1
CSTA cystatin A (stefin A)
CTSB cathepsin B
CTSH cathepsin H
CTSZ cathepsin Z
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DERL1 derlin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EHF ets homologous factor
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FADS1 fatty acid desaturase 1
FAM114A1 family with sequence similarity 114, member A1
FAM198B family with sequence similarity 198, member B
FASN fatty acid synthase
FGG fibrinogen gamma chain
FKBP14 FK506 binding protein 14, 22 kDa
FKBP1A FK506 binding protein 1A, 12kDa
FN1 fibronectin 1
G6PD glucose-6-phosphate dehydrogenase
GDI2 GDP dissociation inhibitor 2
GINS1 GINS complex subunit 1 (Psf1 homolog)
GLUL glutamate-ammonia ligase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB3 high mobility group box 3
HOPX HOP homeobox
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KCTD14 potassium channel tetramerization domain containing 14
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LITAF lipopolysaccharide-induced TNF factor
LOXL1 lysyl oxidase-like 1
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAGEA3 melanoma antigen family A3
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL9 methyltransferase like 9
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MPST mercaptopyruvate sulfurtransferase
MTDH metadherin
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYL1 myosin, light chain 1, alkali; skeletal, fast
NAP1L1 nucleosome assembly protein 1-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMU neuromedin U
NUP85 nucleoporin 85kDa
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PDLIM3 PDZ and LIM domain 3
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
POSTN periostin, osteoblast specific factor
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRAF2 PRA1 domain family, member 2
PRDX4 peroxiredoxin 4
PRSS23 protease, serine, 23
PYCARD PYD and CARD domain containing
RABAC1 Rab acceptor 1 (prenylated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF130 ring finger protein 130
RPN2 ribophorin II
RPS21 ribosomal protein S21
RPS4Y1 ribosomal protein S4, Y-linked 1
RRM2 ribonucleotide reductase M2
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STS steroid sulfatase (microsomal), isozyme S
TALDO1 transaldolase 1
TBC1D16 TBC1 domain family, member 16
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TKT transketolase
TMED2 transmembrane emp24 domain trafficking protein 2
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM109 transmembrane protein 109
TMEM123 transmembrane protein 123
TMEM230 transmembrane protein 230
TMSB15A thymosin beta 15a
TNNI2 troponin I type 2 (skeletal, fast)
TTN titin
TUBB tubulin, beta class I
TXNDC15 thioredoxin domain containing 15
TYMS thymidylate synthetase
UGP2 UDP-glucose pyrophosphorylase 2
VCAN versican
VKORC1 vitamin K epoxide reductase complex, subunit 1
XBP1 X-box binding protein 1