BRD-A26002865_V4877_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

299 genes differentially expressed following the BRD-A26002865_V4877_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABAT 4-aminobutyrate aminotransferase
ADD3 adducin 3 (gamma)
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDOB aldolase B, fructose-bisphosphate
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ATF3 activating transcription factor 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAMBI BMP and activin membrane-bound inhibitor
BGN biglycan
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CCDC28A coiled-coil domain containing 28A
CCND3 cyclin D3
CCNL1 cyclin L1
CHGB chromogranin B
CHKA choline kinase alpha
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL1A1 collagen, type I, alpha 1
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DLX2 distal-less homeobox 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFHD1 EF-hand domain family, member D1
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FABP1 fatty acid binding protein 1, liver
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAGE3 G antigen 3
GSDMB gasdermin B
GUSBP11 glucuronidase, beta pseudogene 11
HIP1R huntingtin interacting protein 1 related
HIST1H1C histone cluster 1, H1c
HIST1H2AM histone cluster 1, H2am
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL17RB interleukin 17 receptor B
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA0922 KIAA0922
KRT20 keratin 20, type I
L1CAM L1 cell adhesion molecule
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LGALS4 lectin, galactoside-binding, soluble, 4
LIMCH1 LIM and calponin homology domains 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAGEB2 melanoma antigen family B2
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MARCH3 membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MT1F metallothionein 1F
NCAM1 neural cell adhesion molecule 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP2 NLR family, pyrin domain containing 2
NOSIP nitric oxide synthase interacting protein
NPC1 Niemann-Pick disease, type C1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDPK1 3-phosphoinositide dependent protein kinase 1
PEG10 paternally expressed 10
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLA2G15 phospholipase A2, group XV
POLB polymerase (DNA directed), beta
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PTBP2 polypyrimidine tract binding protein 2
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RAB29 RAB29, member RAS oncogene family
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAD9A RAD9 homolog A (S. pombe)
RCAN1 regulator of calcineurin 1
RGS16 regulator of G-protein signaling 16
RHOBTB3 Rho-related BTB domain containing 3
RIMS3 regulating synaptic membrane exocytosis 3
RIOK3 RIO kinase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC4 syndecan 4
SFRP1 secreted frizzled-related protein 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPK2 SRSF protein kinase 2
STX7 syntaxin 7
TBC1D31 TBC1 domain family, member 31
TEX10 testis expressed 10
TGFA transforming growth factor, alpha
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TOX thymocyte selection-associated high mobility group box
TP53BP2 tumor protein p53 binding protein 2
TSPAN7 tetraspanin 7
TUFT1 tuftelin 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR19 WD repeat domain 19
WSB1 WD repeat and SOCS box containing 1
ZMAT3 zinc finger, matrin-type 3
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA3 annexin A3
APLP2 amyloid beta (A4) precursor-like protein 2
ARID1A AT rich interactive domain 1A (SWI-like)
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
BCHE butyrylcholinesterase
CA12 carbonic anhydrase XII
CAPN2 calpain 2, (m/II) large subunit
CCNA2 cyclin A2
CCNB2 cyclin B2
CCND1 cyclin D1
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CNPY2 canopy FGF signaling regulator 2
COL6A2 collagen, type VI, alpha 2
COMT catechol-O-methyltransferase
COPS7A COP9 signalosome subunit 7A
CSK c-src tyrosine kinase
CST3 cystatin C
CSTB cystatin B (stefin B)
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
CXCL8 chemokine (C-X-C motif) ligand 8
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
EFS embryonal Fyn-associated substrate
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP3 epithelial membrane protein 3
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
F12 coagulation factor XII (Hageman factor)
FASTKD5 FAST kinase domains 5
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FERMT1 fermitin family member 1
FGFBP1 fibroblast growth factor binding protein 1
FKBP11 FK506 binding protein 11, 19 kDa
FLNA filamin A, alpha
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GANAB glucosidase, alpha; neutral AB
GBE1 glucan (1,4-alpha-), branching enzyme 1
GSTO1 glutathione S-transferase omega 1
GSTP1 glutathione S-transferase pi 1
GTF2H5 general transcription factor IIH, polypeptide 5
HBB hemoglobin, beta
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXB2 homeobox B2
HOXB7 homeobox B7
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
IPO5 importin 5
IRAK1 interleukin-1 receptor-associated kinase 1
KANK2 KN motif and ankyrin repeat domains 2
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KRT13 keratin 13, type I
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LPAR1 lysophosphatidic acid receptor 1
LRP10 low density lipoprotein receptor-related protein 10
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MAPK6 mitogen-activated protein kinase 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MED28 mediator complex subunit 28
MET MET proto-oncogene, receptor tyrosine kinase
METTL9 methyltransferase like 9
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGST2 microsomal glutathione S-transferase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MPZL2 myelin protein zero-like 2
MRPL16 mitochondrial ribosomal protein L16
MSX1 msh homeobox 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYDGF myeloid-derived growth factor
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NOP10 NOP10 ribonucleoprotein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDIA6 protein disulfide isomerase family A, member 6
PGM1 phosphoglucomutase 1
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PON2 paraoxonase 2
PRDX4 peroxiredoxin 4
PRSS23 protease, serine, 23
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RAB13 RAB13, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RBMX RNA binding motif protein, X-linked
RBPMS RNA binding protein with multiple splicing
RCC1 regulator of chromosome condensation 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIN2 Ras and Rab interactor 2
RPL36AL ribosomal protein L36a-like
RRM2 ribonucleotide reductase M2
S100A10 S100 calcium binding protein A10
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
S100A14 S100 calcium binding protein A14
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SACS sacsin molecular chaperone
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMAD3 SMAD family member 3
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPAG7 sperm associated antigen 7
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SPRY2 sprouty homolog 2 (Drosophila)
STEAP1 six transmembrane epithelial antigen of the prostate 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYPL1 synaptophysin-like 1
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TFPI2 tissue factor pathway inhibitor 2
TMEM109 transmembrane protein 109
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TMPRSS4 transmembrane protease, serine 4
TMX1 thioredoxin-related transmembrane protein 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPBG trophoblast glycoprotein
TPM2 tropomyosin 2 (beta)
TRIOBP TRIO and F-actin binding protein
TSPAN6 tetraspanin 6
TSPAN8 tetraspanin 8
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDR82 WD repeat domain 82
WHSC1 Wolf-Hirschhorn syndrome candidate 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBED1 zinc finger, BED-type containing 1