BRD-A26002865_V4877_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

219 genes differentially expressed following the BRD-A26002865_V4877_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL5 acyl-CoA synthetase long-chain family member 5
ADGRG6 adhesion G protein-coupled receptor G6
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ATG3 autophagy related 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZU1 azurocidin 1
BBX bobby sox homolog (Drosophila)
BPTF bromodomain PHD finger transcription factor
BRD2 bromodomain containing 2
C3 complement component 3
CAPN1 calpain 1, (mu/I) large subunit
CD44 CD44 molecule (Indian blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEP350 centrosomal protein 350kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CLTB clathrin, light chain B
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
CPNE3 copine III
CRBN cereblon
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSNK1E casein kinase 1, epsilon
DHRS2 dehydrogenase/reductase (SDR family) member 2
DICER1 dicer 1, ribonuclease type III
DLK1 delta-like 1 homolog (Drosophila)
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FRYL FRY-like
GPRASP1 G protein-coupled receptor associated sorting protein 1
H3F3B H3 histone, family 3B (H3.3B)
HIPK1 homeodomain interacting protein kinase 1
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DMB major histocompatibility complex, class II, DM beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
ING3 inhibitor of growth family, member 3
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KIAA0226L KIAA0226-like
KLF9 Kruppel-like factor 9
KRT23 keratin 23, type I
KYNU kynureninase
LCN2 lipocalin 2
LGMN legumain
LIMCH1 LIM and calponin homology domains 1
LINC00341 long intergenic non-protein coding RNA 341
MBD4 methyl-CpG binding domain protein 4
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
NDRG1 N-myc downstream regulated 1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NKTR natural killer cell triggering receptor
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
NT5E 5'-nucleotidase, ecto (CD73)
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PEG3 paternally expressed 3
PHIP pleckstrin homology domain interacting protein
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCI protein kinase C, iota
PRRC2C proline-rich coiled-coil 2C
RAB25 RAB25, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RB1CC1 RB1-inducible coiled-coil 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
RHOBTB3 Rho-related BTB domain containing 3
S100P S100 calcium binding protein P
SERINC3 serine incorporator 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SF1 splicing factor 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNAI2 snail family zinc finger 2
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SRRM2 serine/arginine repetitive matrix 2
SYK spleen tyrosine kinase
TERF2IP telomeric repeat binding factor 2, interacting protein
TFPI2 tissue factor pathway inhibitor 2
TMEM30B transmembrane protein 30B
TPR translocated promoter region, nuclear basket protein
TRA2A transformer 2 alpha homolog (Drosophila)
TXNIP thioredoxin interacting protein
USP47 ubiquitin specific peptidase 47
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VPS13B vacuolar protein sorting 13 homolog B (yeast)
WNK1 WNK lysine deficient protein kinase 1
ZC3H15 zinc finger CCCH-type containing 15
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
AUTS2 autism susceptibility candidate 2
CALU calumenin
CD81 CD81 molecule
CD99 CD99 molecule
CENPF centromere protein F, 350/400kDa
CETN2 centrin, EF-hand protein, 2
CLIC4 chloride intracellular channel 4
CRABP2 cellular retinoic acid binding protein 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTSC cathepsin C
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP6 dual specificity phosphatase 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ERLIN2 ER lipid raft associated 2
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GOLM1 golgi membrane protein 1
GPX1 glutathione peroxidase 1
GSTA1 glutathione S-transferase alpha 1
GSTP1 glutathione S-transferase pi 1
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1L hematological and neurological expressed 1-like
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL1RN interleukin 1 receptor antagonist
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB5 integrin, beta 5
KAZN kazrin, periplakin interacting protein
KIAA0101 KIAA0101
LDLR low density lipoprotein receptor
LIG1 ligase I, DNA, ATP-dependent
LMNB2 lamin B2
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MACF1 microtubule-actin crosslinking factor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MEX3D mex-3 RNA binding family member D
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAP1L1 nucleosome assembly protein 1-like 1
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
NT5DC2 5'-nucleotidase domain containing 2
NUP62 nucleoporin 62kDa
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAWR PRKC, apoptosis, WT1, regulator
PBX1 pre-B-cell leukemia homeobox 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCNA proliferating cell nuclear antigen
PDIA3 protein disulfide isomerase family A, member 3
PDIA6 protein disulfide isomerase family A, member 6
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PGD phosphogluconate dehydrogenase
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PRSS23 protease, serine, 23
PSAP prosaposin
PTGIS prostaglandin I2 (prostacyclin) synthase
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RAD23B RAD23 homolog B (S. cerevisiae)
RBBP4 retinoblastoma binding protein 4
RBP1 retinol binding protein 1, cellular
RCC1 regulator of chromosome condensation 1
RNF144A ring finger protein 144A
RPIA ribose 5-phosphate isomerase A
RPS11 ribosomal protein S11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SMS spermine synthase
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STMN1 stathmin 1
TMEM230 transmembrane protein 230
TMEM97 transmembrane protein 97
TRIB2 tribbles pseudokinase 2
TSPAN1 tetraspanin 1
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TWF2 twinfilin actin binding protein 2
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNG uracil-DNA glycosylase
VCAN versican
VIM vimentin
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta