BRD-A26002865_V4877_NEU_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

257 genes differentially expressed following the BRD-A26002865_V4877_NEU_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
ADD3 adducin 3 (gamma)
ADORA2B adenosine A2b receptor
AKAP8L A kinase (PRKA) anchor protein 8-like
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMCX3 armadillo repeat containing, X-linked 3
BCL3 B-cell CLL/lymphoma 3
BRD2 bromodomain containing 2
C3 complement component 3
C7 complement component 7
CA12 carbonic anhydrase XII
CAPN1 calpain 1, (mu/I) large subunit
CDC25A cell division cycle 25A
CEP350 centrosomal protein 350kDa
CFD complement factor D (adipsin)
CHD1 chromodomain helicase DNA binding protein 1
CHPT1 choline phosphotransferase 1
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
COPS2 COP9 signalosome subunit 2
CRTC3 CREB regulated transcription coactivator 3
CXCL14 chemokine (C-X-C motif) ligand 14
CYB561 cytochrome b561
CYBA cytochrome b-245, alpha polypeptide
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPP8 dipeptidyl-peptidase 8
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF5 eukaryotic translation initiation factor 5
ELANE elastase, neutrophil expressed
F12 coagulation factor XII (Hageman factor)
FAM193A family with sequence similarity 193, member A
FAM46A family with sequence similarity 46, member A
FKBP11 FK506 binding protein 11, 19 kDa
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO3 forkhead box O3
G0S2 G0/G1 switch 2
GOSR1 golgi SNAP receptor complex member 1
GPATCH8 G patch domain containing 8
GPI glucose-6-phosphate isomerase
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
ING3 inhibitor of growth family, member 3
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLF4 Kruppel-like factor 4 (gut)
KRT10 keratin 10, type I
KRT17 keratin 17, type I
LRRC59 leucine rich repeat containing 59
LTBP3 latent transforming growth factor beta binding protein 3
LUC7L2 LUC7-like 2 (S. cerevisiae)
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAPT microtubule-associated protein tau
MED13 mediator complex subunit 13
MICALL1 MICAL-like 1
MPC1 mitochondrial pyruvate carrier 1
MRPS30 mitochondrial ribosomal protein S30
MVP major vault protein
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit
NCOA1 nuclear receptor coactivator 1
NME3 NME/NM23 nucleoside diphosphate kinase 3
PCOLCE procollagen C-endopeptidase enhancer
PER1 period circadian clock 1
PER2 period circadian clock 2
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PURA purine-rich element binding protein A
RAE1 ribonucleic acid export 1
RB1CC1 RB1-inducible coiled-coil 1
RBBP6 retinoblastoma binding protein 6
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100A9 S100 calcium binding protein A9
SEC24B SEC24 family member B
SETD2 SET domain containing 2
SF1 splicing factor 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLPI secretory leukocyte peptidase inhibitor
SON SON DNA binding protein
SPEN spen family transcriptional repressor
SQSTM1 sequestosome 1
SREBF1 sterol regulatory element binding transcription factor 1
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
SYNGR3 synaptogyrin 3
SYNJ1 synaptojanin 1
TCERG1 transcription elongation regulator 1
TEX10 testis expressed 10
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TNPO3 transportin 3
TSPAN4 tetraspanin 4
TSTA3 tissue specific transplantation antigen P35B
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
USP9X ubiquitin specific peptidase 9, X-linked
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
YTHDC1 YTH domain containing 1
ZFP36 ZFP36 ring finger protein
ZYX zyxin

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ADGRG1 adhesion G protein-coupled receptor G1
ALCAM activated leukocyte cell adhesion molecule
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BSG basigin (Ok blood group)
C14ORF132 chromosome 14 open reading frame 132
C2CD5 C2 calcium-dependent domain containing 5
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CETN2 centrin, EF-hand protein, 2
CLEC7A C-type lectin domain family 7, member A
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COLEC12 collectin sub-family member 12
CRYAB crystallin, alpha B
CTSC cathepsin C
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK1 death-associated protein kinase 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
EMP1 epithelial membrane protein 1
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GIMAP6 GTPase, IMAP family member 6
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPC3 glypican 3
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
H2AFV H2A histone family, member V
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMG20B high mobility group 20B
HMGB2 high mobility group box 2
HMGB3 high mobility group box 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSM1 insulinoma-associated 1
ITGA6 integrin, alpha 6
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LCK LCK proto-oncogene, Src family tyrosine kinase
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LPAR6 lysophosphatidic acid receptor 6
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP1 latent transforming growth factor beta binding protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MANSC1 MANSC domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MB myoglobin
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
NAV2 neuron navigator 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OPHN1 oligophrenin 1
OSBPL10 oxysterol binding protein-like 10
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCNA proliferating cell nuclear antigen
PCSK1 proprotein convertase subtilisin/kexin type 1
PDLIM3 PDZ and LIM domain 3
PFN2 profilin 2
PHGDH phosphoglycerate dehydrogenase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLXND1 plexin D1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBP1 retinol binding protein 1, cellular
RECQL RecQ helicase-like
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
SASH1 SAM and SH3 domain containing 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SMYD2 SET and MYND domain containing 2
SNX10 sorting nexin 10
SQLE squalene epoxidase
SRP9 signal recognition particle 9kDa
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STC1 stanniocalcin 1
STMN1 stathmin 1
SULF1 sulfatase 1
TARP TCR gamma alternate reading frame protein
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMEM2 transmembrane protein 2
TMEM230 transmembrane protein 230
TMEM97 transmembrane protein 97
TMSB15B thymosin beta 15B
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TP53I3 tumor protein p53 inducible protein 3
TPGS2 tubulin polyglutamylase complex subunit 2
TRDV3 T cell receptor delta variable 3
TSC22D1 TSC22 domain family, member 1
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZWINT ZW10 interacting kinetochore protein