BRD-A26002865_V4877_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

280 genes differentially expressed following the BRD-A26002865_V4877_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
ANXA3 annexin A3
ARFIP2 ADP-ribosylation factor interacting protein 2
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCAS2 breast carcinoma amplified sequence 2
BCL3 B-cell CLL/lymphoma 3
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHD1 chromodomain helicase DNA binding protein 1
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
COL11A1 collagen, type XI, alpha 1
COL14A1 collagen, type XIV, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DENND5A DENN/MADD domain containing 5A
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLC1 DLC1 Rho GTPase activating protein
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ECD ecdysoneless homolog (Drosophila)
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
EREG epiregulin
ETNK1 ethanolamine kinase 1
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FAM179B family with sequence similarity 179, member B
FAM53C family with sequence similarity 53, member C
FHL2 four and a half LIM domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2B general transcription factor IIB
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
IER2 immediate early response 2
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFRD1 interferon-related developmental regulator 1
IL6ST interleukin 6 signal transducer
ING3 inhibitor of growth family, member 3
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KIAA1033 KIAA1033
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCL1 myeloid cell leukemia 1
MED17 mediator complex subunit 17
MIR22HG MIR22 host gene
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP98 nucleoporin 98kDa
NUPL1 nucleoporin like 1
NXF1 nuclear RNA export factor 1
ODC1 ornithine decarboxylase 1
OSER1 oxidative stress responsive serine-rich 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRDM2 PR domain containing 2, with ZNF domain
PSME4 proteasome (prosome, macropain) activator subunit 4
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
QKI QKI, KH domain containing, RNA binding
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAE1 ribonucleic acid export 1
RAP1GAP RAP1 GTPase activating protein
RBM39 RNA binding motif protein 39
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNF111 ring finger protein 111
RNMT RNA (guanine-7-) methyltransferase
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAF8 SR-related CTD-associated factor 8
SFRP4 secreted frizzled-related protein 4
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC16A4 solute carrier family 16, member 4
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SON SON DNA binding protein
SPAG9 sperm associated antigen 9
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
STK17B serine/threonine kinase 17b
SYNJ1 synaptojanin 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TERF2IP telomeric repeat binding factor 2, interacting protein
THBS1 thrombospondin 1
THUMPD2 THUMP domain containing 2
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMF1 TATA element modulatory factor 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D2 TSC22 domain family, member 2
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
UBE2B ubiquitin-conjugating enzyme E2B
USP3 ubiquitin specific peptidase 3
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
YTHDC1 YTH domain containing 1
ZFP36 ZFP36 ring finger protein
ZNF410 zinc finger protein 410
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ACTC1 actin, alpha, cardiac muscle 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AHNAK2 AHNAK nucleoprotein 2
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AQP3 aquaporin 3 (Gill blood group)
ATF5 activating transcription factor 5
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCAP31 B-cell receptor-associated protein 31
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CETN2 centrin, EF-hand protein, 2
CLIC4 chloride intracellular channel 4
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL14 chemokine (C-X-C motif) ligand 14
DEFB1 defensin, beta 1
DES desmin
DHCR24 24-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
ENO1 enolase 1, (alpha)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
EYA2 EYA transcriptional coactivator and phosphatase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FOLR1 folate receptor 1 (adult)
GAS6 growth arrest-specific 6
GCLM glutamate-cysteine ligase, modifier subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HMGB3 high mobility group box 3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRAK1 interleukin-1 receptor-associated kinase 1
JCHAIN joining chain of multimeric IgA and IgM
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
LAMP1 lysosomal-associated membrane protein 1
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
MAP1B microtubule-associated protein 1B
MLEC malectin
MREG melanoregulin
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NEFH neurofilament, heavy polypeptide
NES nestin
NUP62 nucleoporin 62kDa
OPN3 opsin 3
PARP1 poly (ADP-ribose) polymerase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCNA proliferating cell nuclear antigen
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PDZK1IP1 PDZK1 interacting protein 1
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PODXL podocalyxin-like
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RPA1 replication protein A1, 70kDa
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SFN stratifin
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STEAP3 STEAP family member 3, metalloreductase
TKT transketolase
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TNS1 tensin 1
TRIM29 tripartite motif containing 29
TUBB tubulin, beta class I
TXN thioredoxin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGP2 UDP-glucose pyrophosphorylase 2
UNG uracil-DNA glycosylase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
YBX3 Y box binding protein 3