BRD-A26002865_V4877_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

214 genes differentially expressed following the BRD-A26002865_V4877_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
AXL AXL receptor tyrosine kinase
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHIC2 cysteine-rich hydrophobic domain 2
CHKA choline kinase alpha
CHRDL1 chordin-like 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
CLU clusterin
CNN3 calponin 3, acidic
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GOLGA4 golgin A4
GSE1 Gse1 coiled-coil protein
HES1 hes family bHLH transcription factor 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL6 interleukin 6
ING3 inhibitor of growth family, member 3
INPP1 inositol polyphosphate-1-phosphatase
IRF1 interferon regulatory factor 1
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KDM5D lysine (K)-specific demethylase 5D
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KRT7 keratin 7, type II
KYNU kynureninase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MGP matrix Gla protein
MT1E metallothionein 1E
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAV3 neuron navigator 3
NCALD neurocalcin delta
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
PER2 period circadian clock 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RBM39 RNA binding motif protein 39
RCOR3 REST corepressor 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RLF rearranged L-myc fusion
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSRC2 arginine/serine-rich coiled-coil 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SRSF11 serine/arginine-rich splicing factor 11
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TESC tescalcin
TEX10 testis expressed 10
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TMEM87A transmembrane protein 87A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TSC22D2 TSC22 domain family, member 2
TXNL4B thioredoxin-like 4B
ZFP36 ZFP36 ring finger protein
ZHX2 zinc fingers and homeoboxes 2
ZNF189 zinc finger protein 189
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
C14ORF132 chromosome 14 open reading frame 132
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CCNB1 cyclin B1
CD14 CD14 molecule
CD163 CD163 molecule
CDK1 cyclin-dependent kinase 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CLTC clathrin, heavy chain (Hc)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DPT dermatopontin
DPYSL2 dihydropyrimidinase-like 2
EMP2 epithelial membrane protein 2
ENO2 enolase 2 (gamma, neuronal)
EPRS glutamyl-prolyl-tRNA synthetase
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
GARS glycyl-tRNA synthetase
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB3 high mobility group box 3
HSPA8 heat shock 70kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KIAA0100 KIAA0100
KIF20A kinesin family member 20A
KRT5 keratin 5, type II
LIPA lipase A, lysosomal acid, cholesterol esterase
LPCAT1 lysophosphatidylcholine acyltransferase 1
LTBP1 latent transforming growth factor beta binding protein 1
LY96 lymphocyte antigen 96
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
METTL9 methyltransferase like 9
MLEC malectin
MME membrane metallo-endopeptidase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NELL2 NEL-like 2 (chicken)
NPC2 Niemann-Pick disease, type C2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCP4 Purkinje cell protein 4
PDE4DIP phosphodiesterase 4D interacting protein
PDGFD platelet derived growth factor D
PDIA6 protein disulfide isomerase family A, member 6
PFN2 profilin 2
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PKM pyruvate kinase, muscle
POU2AF1 POU class 2 associating factor 1
PRDX4 peroxiredoxin 4
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
RAP2A RAP2A, member of RAS oncogene family
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
S100A10 S100 calcium binding protein A10
S100A9 S100 calcium binding protein A9
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TM9SF2 transmembrane 9 superfamily member 2
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TMEM243 transmembrane protein 243, mitochondrial
TMEM47 transmembrane protein 47
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
UNC13B unc-13 homolog B (C. elegans)