BRD-A26002865_V4877_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

293 genes differentially expressed following the BRD-A26002865_V4877_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ANXA1 annexin A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BIRC3 baculoviral IAP repeat containing 3
BRD2 bromodomain containing 2
C10ORF10 chromosome 10 open reading frame 10
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COL10A1 collagen, type X, alpha 1
CRY1 cryptochrome circadian clock 1
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXC1 forkhead box C1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPATCH8 G patch domain containing 8
GTPBP8 GTP-binding protein 8 (putative)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HP haptoglobin
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHMBP2 immunoglobulin mu binding protein 2
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT17 keratin 17, type I
KYNU kynureninase
LDLR low density lipoprotein receptor
LIPG lipase, endothelial
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MICU2 mitochondrial calcium uptake 2
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NACA nascent polypeptide-associated complex alpha subunit
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP1 nuclear receptor interacting protein 1
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
ORC5 origin recognition complex, subunit 5
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PHIP pleckstrin homology domain interacting protein
PLK2 polo-like kinase 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RDX radixin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
RNF111 ring finger protein 111
RPL17 ribosomal protein L17
RRAGD Ras-related GTP binding D
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP4 secreted frizzled-related protein 4
SIK1 salt-inducible kinase 1
SIK3 SIK family kinase 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMNDC1 survival motor neuron domain containing 1
SPEN spen family transcriptional repressor
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
TXNDC9 thioredoxin domain containing 9
TXNL4B thioredoxin-like 4B
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
VCPKMT valosin containing protein lysine (K) methyltransferase
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ADAMDEC1 ADAM-like, decysin 1
AIM1 absent in melanoma 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APLP2 amyloid beta (A4) precursor-like protein 2
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPH aspartate beta-hydroxylase
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF106 chromosome 1 open reading frame 106
CA12 carbonic anhydrase XII
CD200 CD200 molecule
CD320 CD320 molecule
CD58 CD58 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CERK ceramide kinase
CERS6 ceramide synthase 6
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLCA4 chloride channel accessory 4
COLEC12 collectin sub-family member 12
CRABP2 cellular retinoic acid binding protein 2
CTSH cathepsin H
DCK deoxycytidine kinase
DERA deoxyribose-phosphate aldolase (putative)
DOK4 docking protein 4
DPYSL2 dihydropyrimidinase-like 2
EPN2 epsin 2
ERBB2 erb-b2 receptor tyrosine kinase 2
ETV5 ets variant 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX2 glutathione peroxidase 2
GRN granulin
GSTP1 glutathione S-transferase pi 1
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIRA histone cell cycle regulator
HMGB3 high mobility group box 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KRT1 keratin 1, type II
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LPCAT4 lysophosphatidylcholine acyltransferase 4
LRP4 low density lipoprotein receptor-related protein 4
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEGF9 multiple EGF-like-domains 9
METTL7A methyltransferase like 7A
METTL9 methyltransferase like 9
MXRA7 matrix-remodelling associated 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PAM peptidylglycine alpha-amidating monooxygenase
PCGF2 polycomb group ring finger 2
PCP4 Purkinje cell protein 4
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PRSS3 protease, serine, 3
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PSD3 pleckstrin and Sec7 domain containing 3
PSPH phosphoserine phosphatase
PTPRE protein tyrosine phosphatase, receptor type, E
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB15 RAB15, member RAS oncogene family
RAB27A RAB27A, member RAS oncogene family
RCAN1 regulator of calcineurin 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RNASE6 ribonuclease, RNase A family, k6
RNASET2 ribonuclease T2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPA1 replication protein A1, 70kDa
RXRA retinoid X receptor, alpha
S100P S100 calcium binding protein P
SCARB2 scavenger receptor class B, member 2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORBS1 sorbin and SH3 domain containing 1
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINK5 serine peptidase inhibitor, Kazal type 5
SPTBN1 spectrin, beta, non-erythrocytic 1
SST somatostatin
TCF4 transcription factor 4
TM9SF2 transmembrane 9 superfamily member 2
TM9SF3 transmembrane 9 superfamily member 3
TMEM2 transmembrane protein 2
TMEM243 transmembrane protein 243, mitochondrial
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TNNT1 troponin T type 1 (skeletal, slow)
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
UXS1 UDP-glucuronate decarboxylase 1
VPREB1 pre-B lymphocyte 1
WRB tryptophan rich basic protein
ZMYND8 zinc finger, MYND-type containing 8