BRD-A26002865_V4877_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

301 genes differentially expressed following the BRD-A26002865_V4877_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
AZU1 azurocidin 1
BIRC2 baculoviral IAP repeat containing 2
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
C21ORF91 chromosome 21 open reading frame 91
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CARKD carbohydrate kinase domain containing
CCND2 cyclin D2
CCNE2 cyclin E2
CCNL1 cyclin L1
CD44 CD44 molecule (Indian blood group)
CDC7 cell division cycle 7
CDK17 cyclin-dependent kinase 17
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CHIC2 cysteine-rich hydrophobic domain 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN10 claudin 10
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
CRYBG3 beta-gamma crystallin domain containing 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF3D eukaryotic translation initiation factor 3, subunit D
EIF5 eukaryotic translation initiation factor 5
EPHA4 EPH receptor A4
ERBB4 erb-b2 receptor tyrosine kinase 4
ESRRG estrogen-related receptor gamma
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EXOSC8 exosome component 8
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FXYD2 FXYD domain containing ion transport regulator 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GOLGA4 golgin A4
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
HES1 hes family bHLH transcription factor 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IER2 immediate early response 2
IER5 immediate early response 5
IL1B interleukin 1, beta
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF6 Kruppel-like factor 6
KRT7 keratin 7, type II
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIMCH1 LIM and calponin homology domains 1
LIPG lipase, endothelial
LTF lactotransferrin
LYST lysosomal trafficking regulator
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MPO myeloperoxidase
N4BP2L2 NEDD4 binding protein 2-like 2
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NCALD neurocalcin delta
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUPL1 nucleoporin like 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAX8 paired box 8
PAXBP1 PAX3 and PAX7 binding protein 1
PBX3 pre-B-cell leukemia homeobox 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PEG3 paternally expressed 3
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PTBP2 polypyrimidine tract binding protein 2
PTPRM protein tyrosine phosphatase, receptor type, M
RAE1 ribonucleic acid export 1
RDX radixin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RPL17 ribosomal protein L17
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RRAGD Ras-related GTP binding D
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSRC2 arginine/serine-rich coiled-coil 2
SAV1 salvador family WW domain containing protein 1
SCGB2A2 secretoglobin, family 2A, member 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SFRP1 secreted frizzled-related protein 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX9 SRY (sex determining region Y)-box 9
SRRM2 serine/arginine repetitive matrix 2
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBP TATA box binding protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TRA2A transformer 2 alpha homolog (Drosophila)
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
U2SURP U2 snRNP-associated SURP domain containing
UBAP2 ubiquitin associated protein 2
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VCPKMT valosin containing protein lysine (K) methyltransferase
WEE1 WEE1 G2 checkpoint kinase
YTHDC1 YTH domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF410 zinc finger protein 410
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABR active BCR-related
ACSL5 acyl-CoA synthetase long-chain family member 5
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADCY9 adenylate cyclase 9
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
AQP3 aquaporin 3 (Gill blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BID BH3 interacting domain death agonist
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA12 carbonic anhydrase XII
CALD1 caldesmon 1
CANT1 calcium activated nucleotidase 1
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHPT1 choline phosphotransferase 1
CKAP4 cytoskeleton-associated protein 4
CLCA4 chloride channel accessory 4
CLIC1 chloride intracellular channel 1
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CSTB cystatin B (stefin B)
CTSB cathepsin B
CTSZ cathepsin Z
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBN1 drebrin 1
DDAH2 dimethylarginine dimethylaminohydrolase 2
DOK4 docking protein 4
DPYSL2 dihydropyrimidinase-like 2
DSTN destrin (actin depolymerizing factor)
EMP2 epithelial membrane protein 2
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS3 fatty acid desaturase 3
FAM171A1 family with sequence similarity 171, member A1
FAM57A family with sequence similarity 57, member A
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FZD7 frizzled class receptor 7
GLUL glutamate-ammonia ligase
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GREM1 gremlin 1, DAN family BMP antagonist
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HIRA histone cell cycle regulator
HMGB3 high mobility group box 3
HNRNPR heterogeneous nuclear ribonucleoprotein R
HOMER2 homer scaffolding protein 2
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP6 insulin-like growth factor binding protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB1BP1 integrin beta 1 binding protein 1
KANK2 KN motif and ankyrin repeat domains 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF5B kinesin family member 5B
LASP1 LIM and SH3 protein 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPA lipase A, lysosomal acid, cholesterol esterase
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LXN latexin
MALL mal, T-cell differentiation protein-like
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
METTL9 methyltransferase like 9
MKNK2 MAP kinase interacting serine/threonine kinase 2
MPZL1 myelin protein zero-like 1
MSRB2 methionine sulfoxide reductase B2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F6 nuclear receptor subfamily 2, group F, member 6
NT5DC2 5'-nucleotidase domain containing 2
OAT ornithine aminotransferase
PARP1 poly (ADP-ribose) polymerase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCYOX1 prenylcysteine oxidase 1
PDE4DIP phosphodiesterase 4D interacting protein
PDGFD platelet derived growth factor D
PDIA6 protein disulfide isomerase family A, member 6
PDLIM2 PDZ and LIM domain 2 (mystique)
PEG10 paternally expressed 10
PI3 peptidase inhibitor 3, skin-derived
PITX1 paired-like homeodomain 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRR7 proline rich 7 (synaptic)
PRUNE2 prune homolog 2 (Drosophila)
PSD3 pleckstrin and Sec7 domain containing 3
PXDN peroxidasin
RAB31 RAB31, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RBPMS RNA binding protein with multiple splicing
RNASE4 ribonuclease, RNase A family, 4
SDC1 syndecan 1
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SMAGP small cell adhesion glycoprotein
SORBS1 sorbin and SH3 domain containing 1
SORBS3 sorbin and SH3 domain containing 3
SPINK5 serine peptidase inhibitor, Kazal type 5
SPON2 spondin 2, extracellular matrix protein
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TBC1D16 TBC1 domain family, member 16
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TKT transketolase
TMEM14A transmembrane protein 14A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM2 transmembrane protein 2
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TNS3 tensin 3
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
TSEN34 TSEN34 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TXNDC15 thioredoxin domain containing 15
VAT1 vesicle amine transport 1
ZNF586 zinc finger protein 586