BRD-A26002865_V4877_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

371 genes differentially expressed following the BRD-A26002865_V4877_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AKAP8L A kinase (PRKA) anchor protein 8-like
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANKRD12 ankyrin repeat domain 12
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BHLHE40 basic helix-loop-helix family, member e40
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BPGM 2,3-bisphosphoglycerate mutase
BPTF bromodomain PHD finger transcription factor
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
C2CD5 C2 calcium-dependent domain containing 5
C6ORF48 chromosome 6 open reading frame 48
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD24 CD24 molecule
CD83 CD83 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLK4 CDC-like kinase 4
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CPE carboxypeptidase E
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR2 early growth response 2
EPHA2 EPH receptor A2
ETNK1 ethanolamine kinase 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM13B family with sequence similarity 13, member B
FGF13 fibroblast growth factor 13
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRZB frizzled-related protein
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GNPDA1 glucosamine-6-phosphate deaminase 1
GPATCH8 G patch domain containing 8
H3F3B H3 histone, family 3B (H3.3B)
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2AG histone cluster 1, H2ag
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IFIH1 interferon induced with helicase C domain 1
IFRD1 interferon-related developmental regulator 1
IFRD2 interferon-related developmental regulator 2
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
IL6 interleukin 6
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
ITM2A integral membrane protein 2A
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KIAA0907 KIAA0907
KIDINS220 kinase D-interacting substrate, 220kDa
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KYNU kynureninase
LIF leukemia inhibitory factor
LTF lactotransferrin
LUC7L3 LUC7-like 3 (S. cerevisiae)
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP2K3 mitogen-activated protein kinase kinase 3
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MCOLN1 mucolipin 1
MED13 mediator complex subunit 13
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMP9 matrix metallopeptidase 9
NCAM1 neural cell adhesion molecule 1
NCK1 NCK adaptor protein 1
NELL2 NEL-like 2 (chicken)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFYC nuclear transcription factor Y, gamma
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXF1 nuclear RNA export factor 1
OASL 2'-5'-oligoadenylate synthetase-like
OLFML2A olfactomedin-like 2A
PADI2 peptidyl arginine deiminase, type II
PARP12 poly (ADP-ribose) polymerase family, member 12
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDLIM5 PDZ and LIM domain 5
PER2 period circadian clock 2
PHIP pleckstrin homology domain interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PILRB paired immunoglobin-like type 2 receptor beta
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTTG1 pituitary tumor-transforming 1
RAE1 ribonucleic acid export 1
RBM22 RNA binding motif protein 22
RBM39 RNA binding motif protein 39
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RSL1D1 ribosomal L1 domain containing 1
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAFB2 scaffold attachment factor B2
SCGB2A2 secretoglobin, family 2A, member 2
SELE selectin E
SIRT1 sirtuin 1
SLC35G2 solute carrier family 35, member G2
SMC4 structural maintenance of chromosomes 4
SMIM7 small integral membrane protein 7
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SQSTM1 sequestosome 1
SRPK2 SRSF protein kinase 2
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TCERG1 transcription elongation regulator 1
TERF2IP telomeric repeat binding factor 2, interacting protein
TEX10 testis expressed 10
TGFB2 transforming growth factor, beta 2
THUMPD2 THUMP domain containing 2
TICAM1 toll-like receptor adaptor molecule 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNPO1 transportin 1
TP53BP2 tumor protein p53 binding protein 2
TRA2B transformer 2 beta homolog (Drosophila)
TRBC1 T cell receptor beta constant 1
TRIM36 tripartite motif containing 36
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
UBE2H ubiquitin-conjugating enzyme E2H
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
UPP1 uridine phosphorylase 1
USP15 ubiquitin specific peptidase 15
VCAM1 vascular cell adhesion molecule 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YTHDC1 YTH domain containing 1
ZCCHC6 zinc finger, CCHC domain containing 6
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACLY ATP citrate lyase
ACSL1 acyl-CoA synthetase long-chain family member 1
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA4 annexin A4
APMAP adipocyte plasma membrane associated protein
APOC1 apolipoprotein C-I
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
BIN1 bridging integrator 1
BLVRA biliverdin reductase A
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALU calumenin
CCDC92 coiled-coil domain containing 92
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CETN2 centrin, EF-hand protein, 2
CKAP4 cytoskeleton-associated protein 4
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
CNPY2 canopy FGF signaling regulator 2
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CST3 cystatin C
CTSH cathepsin H
CTSL cathepsin L
CTSZ cathepsin Z
CYB5A cytochrome b5 type A (microsomal)
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNASE1L1 deoxyribonuclease I-like 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENDOD1 endonuclease domain containing 1
ENG endoglin
ENO2 enolase 2 (gamma, neuronal)
FADS1 fatty acid desaturase 1
FAM114A1 family with sequence similarity 114, member A1
FAM127A family with sequence similarity 127, member A
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FGG fibrinogen gamma chain
FKBP1A FK506 binding protein 1A, 12kDa
G6PD glucose-6-phosphate dehydrogenase
GHR growth hormone receptor
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNS glucosamine (N-acetyl)-6-sulfatase
GPC4 glypican 4
GSTP1 glutathione S-transferase pi 1
GYG2 glycogenin 2
HEBP2 heme binding protein 2
HMGB3 high mobility group box 3
HOPX HOP homeobox
HOXA10 homeobox A10
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA8 heat shock 70kDa protein 8
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KDM5D lysine (K)-specific demethylase 5D
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LOX lysyl oxidase
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP10 low density lipoprotein receptor-related protein 10
LSP1 lymphocyte-specific protein 1
LYZ lysozyme
MAP4 microtubule-associated protein 4
MFAP5 microfibrillar associated protein 5
MGST3 microsomal glutathione S-transferase 3
MLEC malectin
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NAP1L1 nucleosome assembly protein 1-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NT5DC2 5'-nucleotidase domain containing 2
NXN nucleoredoxin
OAT ornithine aminotransferase
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
P4HB prolyl 4-hydroxylase, beta polypeptide
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDIA6 protein disulfide isomerase family A, member 6
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAF2 PRA1 domain family, member 2
PRDX4 peroxiredoxin 4
PTGIS prostaglandin I2 (prostacyclin) synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB31 RAB31, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RHOQ ras homolog family member Q
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFTPC surfactant protein C
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNN stannin
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPON1 spondin 1, extracellular matrix protein
SPON2 spondin 2, extracellular matrix protein
SRPX2 sushi-repeat containing protein, X-linked 2
STS steroid sulfatase (microsomal), isozyme S
TBC1D16 TBC1 domain family, member 16
THBS2 thrombospondin 2
TKT transketolase
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM109 transmembrane protein 109
TMEM164 transmembrane protein 164
TMEM230 transmembrane protein 230
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TWF2 twinfilin actin binding protein 2
TXNL4A thioredoxin-like 4A
TYRP1 tyrosinase-related protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VKORC1 vitamin K epoxide reductase complex, subunit 1
WFDC1 WAP four-disulfide core domain 1
WFDC2 WAP four-disulfide core domain 2
XPOT exportin, tRNA