BRD-A26002865_V4877_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

283 genes differentially expressed following the BRD-A26002865_V4877_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACAA1 acetyl-CoA acyltransferase 1
ACOT7 acyl-CoA thioesterase 7
AEBP1 AE binding protein 1
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
BRD2 bromodomain containing 2
C18ORF8 chromosome 18 open reading frame 8
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFAP20 cilia and flagella associated protein 20
CHCHD7 coiled-coil-helix-coiled-coil-helix domain containing 7
CHEK2 checkpoint kinase 2
COL10A1 collagen, type X, alpha 1
COMP cartilage oligomeric matrix protein
CTH cystathionine gamma-lyase
CYB5R1 cytochrome b5 reductase 1
CYLD cylindromatosis (turban tumor syndrome)
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EFNB2 ephrin-B2
EGR1 early growth response 1
EIF5B eukaryotic translation initiation factor 5B
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FABP1 fatty acid binding protein 1, liver
FAM46A family with sequence similarity 46, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXO3 forkhead box O3
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA6 GATA binding protein 6
GOLGA8A golgin A8 family, member A
H3F3B H3 histone, family 3B (H3.3B)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H4H histone cluster 1, H4h
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
ICAM3 intercellular adhesion molecule 3
IDI1 isopentenyl-diphosphate delta isomerase 1
IER2 immediate early response 2
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP5 insulin-like growth factor binding protein 5
INPP5F inositol polyphosphate-5-phosphatase F
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KLF6 Kruppel-like factor 6
KRT20 keratin 20, type I
LIMA1 LIM domain and actin binding 1
LPIN1 lipin 1
MAGEB2 melanoma antigen family B2
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAPT microtubule-associated protein tau
MCOLN1 mucolipin 1
MEG3 maternally expressed 3 (non-protein coding)
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MPC1 mitochondrial pyruvate carrier 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NANS N-acetylneuraminic acid synthase
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NOSIP nitric oxide synthase interacting protein
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXF1 nuclear RNA export factor 1
PDPK1 3-phosphoinositide dependent protein kinase 1
PER1 period circadian clock 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G15 phospholipase A2, group XV
POLB polymerase (DNA directed), beta
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRDX2 peroxiredoxin 2
PURA purine-rich element binding protein A
RAD9A RAD9 homolog A (S. pombe)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SATB2 SATB homeobox 2
SEPT6 septin 6
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMC1A structural maintenance of chromosomes 1A
SMYD3 SET and MYND domain containing 3
SNAP25 synaptosomal-associated protein, 25kDa
SRSF7 serine/arginine-rich splicing factor 7
STAT1 signal transducer and activator of transcription 1, 91kDa
STXBP1 syntaxin binding protein 1
SULF1 sulfatase 1
TEX10 testis expressed 10
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TOMM34 translocase of outer mitochondrial membrane 34
TOX thymocyte selection-associated high mobility group box
TSC22D3 TSC22 domain family, member 3
TSTA3 tissue specific transplantation antigen P35B
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
WIPF2 WAS/WASL interacting protein family, member 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBTB18 zinc finger and BTB domain containing 18
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
AES amino-terminal enhancer of split
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ANXA1 annexin A1
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
B3GNT1
BEX1 brain expressed, X-linked 1
BID BH3 interacting domain death agonist
CA12 carbonic anhydrase XII
CADPS2 Ca++-dependent secretion activator 2
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CAPNS1 calpain, small subunit 1
CD93 CD93 molecule
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CNPY2 canopy FGF signaling regulator 2
COA3 cytochrome c oxidase assembly factor 3
COL4A6 collagen, type IV, alpha 6
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CST3 cystatin C
CTSL cathepsin L
CXCL5 chemokine (C-X-C motif) ligand 5
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF5A eukaryotic translation initiation factor 5A
EMP3 epithelial membrane protein 3
FGB fibrinogen beta chain
FSTL1 follistatin-like 1
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS2 growth arrest-specific 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNLY granulysin
GPX2 glutathione peroxidase 2
GSPT2 G1 to S phase transition 2
GSTO1 glutathione S-transferase omega 1
GTPBP8 GTP-binding protein 8 (putative)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HDDC2 HD domain containing 2
HMOX1 heme oxygenase 1
HN1L hematological and neurological expressed 1-like
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IGFBP4 insulin-like growth factor binding protein 4
IGFBP6 insulin-like growth factor binding protein 6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IPO5 importin 5
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
KRT81 keratin 81, type II
KYNU kynureninase
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LPAR6 lysophosphatidic acid receptor 6
LY6D lymphocyte antigen 6 complex, locus D
LYZ lysozyme
MAPK6 mitogen-activated protein kinase 6
MARCKSL1 MARCKS-like 1
METTL9 methyltransferase like 9
MGST2 microsomal glutathione S-transferase 2
MLPH melanophilin
MMP7 matrix metallopeptidase 7
MREG melanoregulin
MRPL34 mitochondrial ribosomal protein L34
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBN nibrin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NKG7 natural killer cell granule protein 7
NPY1R neuropeptide Y receptor Y1
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
NRP1 neuropilin 1
NTS neurotensin
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDGFD platelet derived growth factor D
PDLIM4 PDZ and LIM domain 4
PDZK1IP1 PDZK1 interacting protein 1
PGD phosphogluconate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PRDX3 peroxiredoxin 3
PRDX4 peroxiredoxin 4
PRF1 perforin 1 (pore forming protein)
PRSS23 protease, serine, 23
RAB13 RAB13, member RAS oncogene family
RBP1 retinol binding protein 1, cellular
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RIN2 Ras and Rab interactor 2
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFN stratifin
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
SPON2 spondin 2, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYPL1 synaptophysin-like 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
TM4SF1 transmembrane 4 L six family member 1
TMEM97 transmembrane protein 97
TMX1 thioredoxin-related transmembrane protein 1
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TUSC3 tumor suppressor candidate 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UQCRC2 ubiquinol-cytochrome c reductase core protein II
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
URI1 URI1, prefoldin-like chaperone
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L1 ZFP36 ring finger protein-like 1