BRD-A25775766_Securinine_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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39 genes differentially expressed following the BRD-A25775766_Securinine_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
BIRC3 baculoviral IAP repeat containing 3
CXCL8 chemokine (C-X-C motif) ligand 8
ENO2 enolase 2 (gamma, neuronal)
HMOX1 heme oxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
LOX lysyl oxidase
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PHLDA2 pleckstrin homology-like domain, family A, member 2
PI3 peptidase inhibitor 3, skin-derived
S100A7 S100 calcium binding protein A7
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
STC1 stanniocalcin 1
TXNRD1 thioredoxin reductase 1

decreased expression

Symbol Name
ARHGAP29 Rho GTPase activating protein 29
CAV2 caveolin 2
CFI complement factor I
COL3A1 collagen, type III, alpha 1
CTSG cathepsin G
FMO2 flavin containing monooxygenase 2 (non-functional)
G0S2 G0/G1 switch 2
HCP5 HLA complex P5 (non-protein coding)
HNMT histamine N-methyltransferase
IGFBP7 insulin-like growth factor binding protein 7
LUM lumican
LXN latexin
NFIB nuclear factor I/B
NID1 nidogen 1
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SEPP1 selenoprotein P, plasma, 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
TACSTD2 tumor-associated calcium signal transducer 2
WFDC2 WAP four-disulfide core domain 2
ZBTB16 zinc finger and BTB domain containing 16