BRD-A25775766_Securinine_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

93 genes differentially expressed following the BRD-A25775766_Securinine_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
ANPEP alanyl (membrane) aminopeptidase
ASS1 argininosuccinate synthase 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEMIP cell migration inducing protein, hyaluronan binding
CES1 carboxylesterase 1
CKAP4 cytoskeleton-associated protein 4
COTL1 coactosin-like F-actin binding protein 1
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EPAS1 endothelial PAS domain protein 1
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HIP1 huntingtin interacting protein 1
HMOX1 heme oxygenase 1
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KDM5D lysine (K)-specific demethylase 5D
KYNU kynureninase
NEFL neurofilament, light polypeptide
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PERP PERP, TP53 apoptosis effector
PIR pirin (iron-binding nuclear protein)
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VCAN versican

decreased expression

Symbol Name
AGR2 anterior gradient 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCHE butyrylcholinesterase
BST2 bone marrow stromal cell antigen 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD24 CD24 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
CNN3 calponin 3, acidic
CXCL2 chemokine (C-X-C motif) ligand 2
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EFNB2 ephrin-B2
EGR3 early growth response 3
FHL1 four and a half LIM domains 1
GBP1 guanylate binding protein 1, interferon-inducible
GOLM1 golgi membrane protein 1
GPX3 glutathione peroxidase 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IQGAP2 IQ motif containing GTPase activating protein 2
IRS2 insulin receptor substrate 2
LEF1 lymphoid enhancer-binding factor 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LUM lumican
MMD monocyte to macrophage differentiation-associated
MRPS16 mitochondrial ribosomal protein S16
MTA1 metastasis associated 1
N4BP2L2 NEDD4 binding protein 2-like 2
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae)
PRDX2 peroxiredoxin 2
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
RGS1 regulator of G-protein signaling 1
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SORBS1 sorbin and SH3 domain containing 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN1 spectrin, beta, non-erythrocytic 1
TBC1D4 TBC1 domain family, member 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM7SF2 transmembrane 7 superfamily member 2
TSPAN13 tetraspanin 13
XIST X inactive specific transcript (non-protein coding)