BRD-A25775766_Securinine_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

158 genes differentially expressed following the BRD-A25775766_Securinine_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
AHR aryl hydrocarbon receptor
ANXA10 annexin A10
APLP2 amyloid beta (A4) precursor-like protein 2
AQP9 aquaporin 9
BID BH3 interacting domain death agonist
BMP4 bone morphogenetic protein 4
BPHL biphenyl hydrolase-like (serine hydrolase)
CA2 carbonic anhydrase II
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCR4 chemokine (C-X-C motif) receptor 4
DENND1B DENN/MADD domain containing 1B
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCGBP Fc fragment of IgG binding protein
FKBP1B FK506 binding protein 1B, 12.6 kDa
FRY furry homolog (Drosophila)
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GMPR guanosine monophosphate reductase
GPC1 glypican 1
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
HPSE heparanase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IL13RA2 interleukin 13 receptor, alpha 2
LAMP3 lysosomal-associated membrane protein 3
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MDK midkine (neurite growth-promoting factor 2)
MT1F metallothionein 1F
MX1 MX dynamin-like GTPase 1
NELL2 NEL-like 2 (chicken)
NQO1 NAD(P)H dehydrogenase, quinone 1
NQO2 NAD(P)H dehydrogenase, quinone 2
NRGN neurogranin (protein kinase C substrate, RC3)
PDPN podoplanin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PRRC2C proline-rich coiled-coil 2C
PRUNE2 prune homolog 2 (Drosophila)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SDC1 syndecan 1
SELENBP1 selenium binding protein 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAP29 synaptosomal-associated protein, 29kDa
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQSTM1 sequestosome 1
SSBP2 single-stranded DNA binding protein 2
SUSD4 sushi domain containing 4
SYT1 synaptotagmin I
TDP2 tyrosyl-DNA phosphodiesterase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM5 transmembrane protein 5
TPR translocated promoter region, nuclear basket protein
TXNRD1 thioredoxin reductase 1
VSNL1 visinin-like 1

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL3 acyl-CoA synthetase long-chain family member 3
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTA2 actin, alpha 2, smooth muscle, aorta
AK4 adenylate kinase 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA3 annexin A3
APOD apolipoprotein D
APOLD1 apolipoprotein L domain containing 1
ATMIN ATM interactor
C8ORF4 chromosome 8 open reading frame 4
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHPT1 choline phosphotransferase 1
CHRDL1 chordin-like 1
COL14A1 collagen, type XIV, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR7 7-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
EVL Enah/Vasp-like
FABP7 fatty acid binding protein 7, brain
FASN fatty acid synthase
FSTL3 follistatin-like 3 (secreted glycoprotein)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPX3 glutathione peroxidase 3
GRAMD3 GRAM domain containing 3
GRB10 growth factor receptor-bound protein 10
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF1R insulin-like growth factor 1 receptor
IGLJ3 immunoglobulin lambda joining 3
IL32 interleukin 32
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LDLR low density lipoprotein receptor
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MARCKS myristoylated alanine-rich protein kinase C substrate
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MGP matrix Gla protein
MPRIP myosin phosphatase Rho interacting protein
NDN necdin, melanoma antigen (MAGE) family member
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
PDLIM1 PDZ and LIM domain 1
PDZK1 PDZ domain containing 1
PGM1 phosphoglucomutase 1
PMEPA1 prostate transmembrane protein, androgen induced 1
PTGES prostaglandin E synthase
PTGIS prostaglandin I2 (prostacyclin) synthase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCEL sciellin
SCRG1 stimulator of chondrogenesis 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SETBP1 SET binding protein 1
SFRP1 secreted frizzled-related protein 1
SIK1 salt-inducible kinase 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
SPTAN1 spectrin, alpha, non-erythrocytic 1
SQLE squalene epoxidase
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNC tenascin C
TSC22D3 TSC22 domain family, member 3
XBP1 X-box binding protein 1