BRD-A25736793_everolimus_PC3_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-A25736793_everolimus_PC3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AMIGO2 adhesion molecule with Ig-like domain 2
AMOTL2 angiomotin like 2
ATP9A ATPase, class II, type 9A
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EMP1 epithelial membrane protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM46A family with sequence similarity 46, member A
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GRN granulin
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-E major histocompatibility complex, class I, E
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
INSR insulin receptor
ITGB5 integrin, beta 5
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5D lysine (K)-specific demethylase 5D
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LAMA2 laminin, alpha 2
LAMA3 laminin, alpha 3
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LXN latexin
MAN1C1 mannosidase, alpha, class 1C, member 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MYO6 myosin VI
NPTX2 neuronal pentraxin II
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRSS23 protease, serine, 23
RAB13 RAB13, member RAS oncogene family
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SEPP1 selenoprotein P, plasma, 1
SYT1 synaptotagmin I
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TNS3 tensin 3
TSPAN13 tetraspanin 13
TXNIP thioredoxin interacting protein
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HSPH1 heat shock 105kDa/110kDa protein 1
KRT16 keratin 16, type I
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTF lactotransferrin
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RRM2 ribonucleotide reductase M2
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC43A3 solute carrier family 43, member 3
SMC1A structural maintenance of chromosomes 1A
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
XIST X inactive specific transcript (non-protein coding)