BRD-A25736793_everolimus_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

127 genes differentially expressed following the BRD-A25736793_everolimus_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADAMDEC1 ADAM-like, decysin 1
AGR2 anterior gradient 2
ANO10 anoctamin 10
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
ATP9A ATPase, class II, type 9A
BASP1 brain abundant, membrane attached signal protein 1
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CP ceruloplasmin (ferroxidase)
CTGF connective tissue growth factor
CXCL5 chemokine (C-X-C motif) ligand 5
DUSP6 dual specificity phosphatase 6
DYNLT3 dynein, light chain, Tctex-type 3
EFNB2 ephrin-B2
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FBN2 fibrillin 2
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FUCA1 fucosidase, alpha-L- 1, tissue
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GAS6 growth arrest-specific 6
GRN granulin
GSN gelsolin
HOXB6 homeobox B6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IRS1 insulin receptor substrate 1
JAG1 jagged 1
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR1 lysophosphatidic acid receptor 1
LXN latexin
MAN1C1 mannosidase, alpha, class 1C, member 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
NET1 neuroepithelial cell transforming 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFD platelet derived growth factor D
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLAU plasminogen activator, urokinase
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PLS3 plastin 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PRSS23 protease, serine, 23
PTX3 pentraxin 3, long
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGCE sarcoglycan, epsilon
SOX9 SRY (sex determining region Y)-box 9
SSBP2 single-stranded DNA binding protein 2
STAB1 stabilin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TNS3 tensin 3
TUBA1A tubulin, alpha 1a
TWIST1 twist family bHLH transcription factor 1
TXNIP thioredoxin interacting protein
VEGFC vascular endothelial growth factor C
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACSL1 acyl-CoA synthetase long-chain family member 1
ADA adenosine deaminase
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BCHE butyrylcholinesterase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CDC6 cell division cycle 6
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DPT dermatopontin
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELOVL5 ELOVL fatty acid elongase 5
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GREB1 growth regulation by estrogen in breast cancer 1
GUSBP3 glucuronidase, beta pseudogene 3
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KRT15 keratin 15, type I
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MCM10 minichromosome maintenance complex component 10
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MRPS2 mitochondrial ribosomal protein S2
NEFH neurofilament, heavy polypeptide
ODC1 ornithine decarboxylase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A9 S100 calcium binding protein A9
SFTPA2 surfactant protein A2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SRSF7 serine/arginine-rich splicing factor 7
TYMS thymidylate synthetase