BRD-A25736793_everolimus_MCF7_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-A25736793_everolimus_MCF7_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY1 adenylate cyclase 1 (brain)
ADGRG6 adhesion G protein-coupled receptor G6
AMDHD2 amidohydrolase domain containing 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
BEX1 brain expressed, X-linked 1
CCNG2 cyclin G2
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
EIF1 eukaryotic translation initiation factor 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM69A family with sequence similarity 69, member A
FBN2 fibrillin 2
FBXO11 F-box protein 11
GATA3 GATA binding protein 3
GRN granulin
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
IGHD immunoglobulin heavy constant delta
IGKV4-1 immunoglobulin kappa variable 4-1
ITGB5 integrin, beta 5
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRIP1 nuclear receptor interacting protein 1
OLFM4 olfactomedin 4
OSR2 odd-skipped related transciption factor 2
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PFKM phosphofructokinase, muscle
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PXDN peroxidasin
QPCT glutaminyl-peptide cyclotransferase
RAB21 RAB21, member RAS oncogene family
SAMD4A sterile alpha motif domain containing 4A
SAT1 spermidine/spermine N1-acetyltransferase 1
SH3YL1 SH3 and SYLF domain containing 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TRIP6 thyroid hormone receptor interactor 6
TTC3 tetratricopeptide repeat domain 3
WNT5A wingless-type MMTV integration site family, member 5A
YPEL5 yippee-like 5 (Drosophila)
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
AUTS2 autism susceptibility candidate 2
BAG2 BCL2-associated athanogene 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C7 complement component 7
CCL5 chemokine (C-C motif) ligand 5
CD99 CD99 molecule
CFH complement factor H
CLIC5 chloride intracellular channel 5
COL1A2 collagen, type I, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
FAM129A family with sequence similarity 129, member A
FXYD5 FXYD domain containing ion transport regulator 5
G0S2 G0/G1 switch 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GEM GTP binding protein overexpressed in skeletal muscle
GPX2 glutathione peroxidase 2
GTF2A2 general transcription factor IIA, 2, 12kDa
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
IGFBP5 insulin-like growth factor binding protein 5
ITM2A integral membrane protein 2A
LMO4 LIM domain only 4
LYZ lysozyme
MEIS2 Meis homeobox 2
MYH11 myosin, heavy chain 11, smooth muscle
NFE2L2 nuclear factor, erythroid 2-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
PEG10 paternally expressed 10
PLS1 plastin 1
RAD51C RAD51 paralog C
S100A6 S100 calcium binding protein A6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
TAGLN transgelin
TCTN1 tectonic family member 1
TNC tenascin C
TPM4 tropomyosin 4