BRD-A25736793_everolimus_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-A25736793_everolimus_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ACTN1 actinin, alpha 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDOB aldolase B, fructose-bisphosphate
AREG amphiregulin
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
CRABP1 cellular retinoic acid binding protein 1
DMTF1 cyclin D binding myb-like transcription factor 1
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FHL2 four and a half LIM domains 2
GSTM3 glutathione S-transferase mu 3 (brain)
IER3 immediate early response 3
IGFBP4 insulin-like growth factor binding protein 4
INHBB inhibin, beta B
ITGB5 integrin, beta 5
ITM2A integral membrane protein 2A
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LGALS4 lectin, galactoside-binding, soluble, 4
LRP10 low density lipoprotein receptor-related protein 10
LY75 lymphocyte antigen 75
MAP1B microtubule-associated protein 1B
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKSL1 MARCKS-like 1
MGLL monoglyceride lipase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLA2G16 phospholipase A2, group XVI
PROM1 prominin 1
RGS5 regulator of G-protein signaling 5
S100A6 S100 calcium binding protein A6
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SKAP2 src kinase associated phosphoprotein 2
SOX9 SRY (sex determining region Y)-box 9
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TPM1 tropomyosin 1 (alpha)
TSC22D2 TSC22 domain family, member 2
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
BEX1 brain expressed, X-linked 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CHL1 cell adhesion molecule L1-like
CLU clusterin
CSTA cystatin A (stefin A)
ELANE elastase, neutrophil expressed
ESR1 estrogen receptor 1
FAM134B family with sequence similarity 134, member B
FAM46C family with sequence similarity 46, member C
GATA3 GATA binding protein 3
GCH1 GTP cyclohydrolase 1
GTPBP4 GTP binding protein 4
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
LTF lactotransferrin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MUC16 mucin 16, cell surface associated
PHGDH phosphoglycerate dehydrogenase
RAD51C RAD51 paralog C
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLPI secretory leukocyte peptidase inhibitor
SPON1 spondin 1, extracellular matrix protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM100 transmembrane protein 100
YME1L1 YME1-like 1 ATPase