BRD-A25736793_everolimus_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-A25736793_everolimus_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASPH aspartate beta-hydroxylase
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CD52 CD52 molecule
CP ceruloplasmin (ferroxidase)
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL9 chemokine (C-X-C motif) ligand 9
DUSP6 dual specificity phosphatase 6
FHL1 four and a half LIM domains 1
FXYD2 FXYD domain containing ion transport regulator 2
GPX4 glutathione peroxidase 4
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDS iduronate 2-sulfatase
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
LDOC1 leucine zipper, down-regulated in cancer 1
MET MET proto-oncogene, receptor tyrosine kinase
NQO1 NAD(P)H dehydrogenase, quinone 1
PON2 paraoxonase 2
PRAF2 PRA1 domain family, member 2
RAB4A RAB4A, member RAS oncogene family
RGS1 regulator of G-protein signaling 1
SPRED2 sprouty-related, EVH1 domain containing 2
STAT1 signal transducer and activator of transcription 1, 91kDa
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
WDTC1 WD and tetratricopeptide repeats 1

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASCL1 achaete-scute family bHLH transcription factor 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALML4 calmodulin-like 4
CCL2 chemokine (C-C motif) ligand 2
CDC20 cell division cycle 20
CDC42 cell division cycle 42
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
COL9A3 collagen, type IX, alpha 3
CSRP1 cysteine and glycine-rich protein 1
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENOPH1 enolase-phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
HBB hemoglobin, beta
HEPH hephaestin
ICAM2 intercellular adhesion molecule 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
LMO4 LIM domain only 4
MCAM melanoma cell adhesion molecule
MEF2C myocyte enhancer factor 2C
MSMB microseminoprotein, beta-
NES nestin
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OGN osteoglycin
PDIA6 protein disulfide isomerase family A, member 6
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RBP1 retinol binding protein 1, cellular
RPIA ribose 5-phosphate isomerase A
RRBP1 ribosome binding protein 1
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
VCAN versican
ZNF274 zinc finger protein 274