BRD-A25736793_everolimus_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-A25736793_everolimus_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ACVR1B activin A receptor, type IB
ADGRE5 adhesion G protein-coupled receptor E5
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
C6ORF48 chromosome 6 open reading frame 48
CCDC92 coiled-coil domain containing 92
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN10 claudin 10
CPD carboxypeptidase D
CPT1A carnitine palmitoyltransferase 1A (liver)
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CTSD cathepsin D
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAZAP2 DAZ associated protein 2
DEFB1 defensin, beta 1
EIF3F eukaryotic translation initiation factor 3, subunit F
EIF4B eukaryotic translation initiation factor 4B
EPS8 epidermal growth factor receptor pathway substrate 8
FXYD2 FXYD domain containing ion transport regulator 2
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGF1R insulin-like growth factor 1 receptor
LMNA lamin A/C
MAGED1 melanoma antigen family D1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NNMT nicotinamide N-methyltransferase
NUPR1 nuclear protein, transcriptional regulator, 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAF2 PRA1 domain family, member 2
RAB13 RAB13, member RAS oncogene family
SEPP1 selenoprotein P, plasma, 1
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TRIP6 thyroid hormone receptor interactor 6
TSC22D3 TSC22 domain family, member 3
WDTC1 WD and tetratricopeptide repeats 1
WFDC2 WAP four-disulfide core domain 2
YBX3 Y box binding protein 3
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BCL2A1 BCL2-related protein A1
C1QBP complement component 1, q subcomponent binding protein
CCDC86 coiled-coil domain containing 86
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL14 chemokine (C-X-C motif) ligand 14
CYBB cytochrome b-245, beta polypeptide
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5 eukaryotic translation initiation factor 5
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FKBP4 FK506 binding protein 4, 59kDa
GPM6B glycoprotein M6B
HILPDA hypoxia inducible lipid droplet-associated
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IGFBP3 insulin-like growth factor binding protein 3
JCHAIN joining chain of multimeric IgA and IgM
KCTD12 potassium channel tetramerization domain containing 12
KLK11 kallikrein-related peptidase 11
LAP3 leucine aminopeptidase 3
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIPG lipase, endothelial
LTF lactotransferrin
LYST lysosomal trafficking regulator
LYZ lysozyme
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MMP8 matrix metallopeptidase 8
NAMPT nicotinamide phosphoribosyltransferase
NES nestin
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
PDLIM1 PDZ and LIM domain 1
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PMP22 peripheral myelin protein 22
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PRAME preferentially expressed antigen in melanoma
PRPF4 pre-mRNA processing factor 4
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAD23B RAD23 homolog B (S. cerevisiae)
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SNX7 sorting nexin 7
SORBS1 sorbin and SH3 domain containing 1
SPARCL1 SPARC-like 1 (hevin)
SYNM synemin, intermediate filament protein
TFRC transferrin receptor
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VDAC1 voltage-dependent anion channel 1