BRD-A25736793_everolimus_HA1E_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

118 genes differentially expressed following the BRD-A25736793_everolimus_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACACB acetyl-CoA carboxylase beta
APOD apolipoprotein D
AREG amphiregulin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CNN1 calponin 1, basic, smooth muscle
DHDDS dehydrodolichyl diphosphate synthase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
E2F2 E2F transcription factor 2
FBLN1 fibulin 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLUL glutamate-ammonia ligase
GPC3 glypican 3
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXA5 homeobox A5
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT23 keratin 23, type I
MAGEA3 melanoma antigen family A3
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MEIS2 Meis homeobox 2
MLPH melanophilin
MOK MOK protein kinase
OLFM4 olfactomedin 4
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PENK proenkephalin
POSTN periostin, osteoblast specific factor
PPAP2C phosphatidic acid phosphatase type 2C
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB4A RAB4A, member RAS oncogene family
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORBS2 sorbin and SH3 domain containing 2
SRPX sushi-repeat containing protein, X-linked
SYNM synemin, intermediate filament protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TESC tescalcin
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
UGCG UDP-glucose ceramide glucosyltransferase
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AK4 adenylate kinase 4
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BCL2A1 BCL2-related protein A1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CBS cystathionine-beta-synthase
CD47 CD47 molecule
CFI complement factor I
CLEC2B C-type lectin domain family 2, member B
CLIC5 chloride intracellular channel 5
CP ceruloplasmin (ferroxidase)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
EGLN3 egl-9 family hypoxia-inducible factor 3
ENO1 enolase 1, (alpha)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM162A family with sequence similarity 162, member A
GARS glycyl-tRNA synthetase
HILPDA hypoxia inducible lipid droplet-associated
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGFBP5 insulin-like growth factor binding protein 5
IL1R2 interleukin 1 receptor, type II
KLK10 kallikrein-related peptidase 10
KLK8 kallikrein-related peptidase 8
LMO3 LIM domain only 3 (rhombotin-like 2)
LMO4 LIM domain only 4
LOC100505650 uncharacterized LOC100505650
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MSMO1 methylsterol monooxygenase 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NRN1 neuritin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAX8 paired box 8
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLTP phospholipid transfer protein
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
REXO2 RNA exonuclease 2
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPAG4 sperm associated antigen 4
SRRM2 serine/arginine repetitive matrix 2
TMEM100 transmembrane protein 100
TNC tenascin C
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNS3 tensin 3
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)