BRD-A25736793_everolimus_HA1E_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-A25736793_everolimus_HA1E_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AKT3 v-akt murine thymoma viral oncogene homolog 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CCND1 cyclin D1
CECR1 cat eye syndrome chromosome region, candidate 1
CXCL12 chemokine (C-X-C motif) ligand 12
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
EGF epidermal growth factor
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
FBLN5 fibulin 5
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GSTA1 glutathione S-transferase alpha 1
GUSB glucuronidase, beta
HOXA5 homeobox A5
HOXD1 homeobox D1
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KRT19 keratin 19, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LMCD1 LIM and cysteine-rich domains 1
MAMLD1 mastermind-like domain containing 1
MFAP2 microfibrillar-associated protein 2
MIA melanoma inhibitory activity
MTA1 metastasis associated 1
NID1 nidogen 1
POSTN periostin, osteoblast specific factor
PTGIS prostaglandin I2 (prostacyclin) synthase
RGS4 regulator of G-protein signaling 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
TLE4 transducin-like enhancer of split 4
UBE3B ubiquitin protein ligase E3B
WFDC2 WAP four-disulfide core domain 2
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ADK adenosine kinase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CA9 carbonic anhydrase IX
CBR1 carbonyl reductase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLIC3 chloride intracellular channel 3
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
FAM107A family with sequence similarity 107, member A
FAM162A family with sequence similarity 162, member A
FERMT1 fermitin family member 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HIST1H2AC histone cluster 1, H2ac
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
INSIG2 insulin induced gene 2
KCNK3 potassium channel, two pore domain subfamily K, member 3
KLF4 Kruppel-like factor 4 (gut)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MMP12 matrix metallopeptidase 12
MRPS16 mitochondrial ribosomal protein S16
NRN1 neuritin 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHGDH phosphoglycerate dehydrogenase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PNP purine nucleoside phosphorylase
PRDX4 peroxiredoxin 4
PSD3 pleckstrin and Sec7 domain containing 3
REXO2 RNA exonuclease 2
S100A8 S100 calcium binding protein A8
SERINC5 serine incorporator 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOCS2 suppressor of cytokine signaling 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
UGP2 UDP-glucose pyrophosphorylase 2
ZNF274 zinc finger protein 274