BRD-A25736793_everolimus_A375_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

107 genes differentially expressed following the BRD-A25736793_everolimus_A375_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
AGA aspartylglucosaminidase
ALDOA aldolase A, fructose-bisphosphate
ARMCX2 armadillo repeat containing, X-linked 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC3 chloride intracellular channel 3
COL5A2 collagen, type V, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CSRP1 cysteine and glycine-rich protein 1
CXCL14 chemokine (C-X-C motif) ligand 14
DNASE1L1 deoxyribonuclease I-like 1
DYNLT3 dynein, light chain, Tctex-type 3
ECM1 extracellular matrix protein 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EIF5A eukaryotic translation initiation factor 5A
ETV1 ets variant 1
ETV5 ets variant 5
EVI2A ecotropic viral integration site 2A
FN1 fibronectin 1
FXYD3 FXYD domain containing ion transport regulator 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
HMGA2 high mobility group AT-hook 2
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
INHBA inhibin, beta A
LGALS1 lectin, galactoside-binding, soluble, 1
MAGED1 melanoma antigen family D1
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MRPS33 mitochondrial ribosomal protein S33
MSRB2 methionine sulfoxide reductase B2
NEB nebulin
NPDC1 neural proliferation, differentiation and control, 1
NPR3 natriuretic peptide receptor 3
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRO protein tyrosine phosphatase, receptor type, O
RHOBTB3 Rho-related BTB domain containing 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RTN2 reticulon 2
SATB2 SATB homeobox 2
SCCPDH saccharopine dehydrogenase (putative)
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC22A18 solute carrier family 22, member 18
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SPRR1B small proline-rich protein 1B
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
TF transferrin
TIMP1 TIMP metallopeptidase inhibitor 1
TNNT1 troponin T type 1 (skeletal, slow)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TST thiosulfate sulfurtransferase (rhodanese)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAN versican

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAD BCL2-associated agonist of cell death
BCHE butyrylcholinesterase
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLU clusterin
EPHA3 EPH receptor A3
GRWD1 glutamate-rich WD repeat containing 1
HSPA1A heat shock 70kDa protein 1A
MLF1 myeloid leukemia factor 1
MUC4 mucin 4, cell surface associated
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
ODC1 ornithine decarboxylase 1
PEA15 phosphoprotein enriched in astrocytes 15
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPS5 ribosomal protein S5
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STMN2 stathmin 2
TARS threonyl-tRNA synthetase
TGM2 transglutaminase 2
TMEM47 transmembrane protein 47
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
VLDLR very low density lipoprotein receptor