BRD-A25736793_everolimus_A375_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

139 genes differentially expressed following the BRD-A25736793_everolimus_A375_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA2 actin, alpha 2, smooth muscle, aorta
ALDOA aldolase A, fructose-bisphosphate
BACE2 beta-site APP-cleaving enzyme 2
C1ORF106 chromosome 1 open reading frame 106
CD24 CD24 molecule
CES1 carboxylesterase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
CSRP1 cysteine and glycine-rich protein 1
CYBA cytochrome b-245, alpha polypeptide
DKK1 dickkopf WNT signaling pathway inhibitor 1
DSP desmoplakin
DUSP10 dual specificity phosphatase 10
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FBXL12 F-box and leucine-rich repeat protein 12
FN1 fibronectin 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GSTP1 glutathione S-transferase pi 1
H2AFY2 H2A histone family, member Y2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
IGF1R insulin-like growth factor 1 receptor
IRS2 insulin receptor substrate 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDM5B lysine (K)-specific demethylase 5B
KDM6B lysine (K)-specific demethylase 6B
KRT14 keratin 14, type I
KRT23 keratin 23, type I
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGED1 melanoma antigen family D1
MMP2 matrix metallopeptidase 2
MRPL33 mitochondrial ribosomal protein L33
MRPS16 mitochondrial ribosomal protein S16
MTSS1 metastasis suppressor 1
MX2 MX dynamin-like GTPase 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NREP neuronal regeneration related protein
NTS neurotensin
PER2 period circadian clock 2
PIEZO2 piezo-type mechanosensitive ion channel component 2
PLSCR3 phospholipid scramblase 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PRAF2 PRA1 domain family, member 2
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
RBKS ribokinase
RPL36 ribosomal protein L36
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
SEPP1 selenoprotein P, plasma, 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SPEN spen family transcriptional repressor
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
TAGLN2 transgelin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS2 thrombospondin 2
TMEM230 transmembrane protein 230
TPM1 tropomyosin 1 (alpha)
TRIOBP TRIO and F-actin binding protein
TUBA1A tubulin, alpha 1a
TUG1 taurine up-regulated 1 (non-protein coding)
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPK1B uroplakin 1B
VCAN versican
VDAC1 voltage-dependent anion channel 1
WBP5 WW domain binding protein 5
WDTC1 WD and tetratricopeptide repeats 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRG1 adhesion G protein-coupled receptor G1
ALDOC aldolase C, fructose-bisphosphate
AQP3 aquaporin 3 (Gill blood group)
ARMT1 acidic residue methyltransferase 1
BLNK B-cell linker
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CA2 carbonic anhydrase II
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CLU clusterin
CYTIP cytohesin 1 interacting protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EDNRB endothelin receptor type B
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FAM13A family with sequence similarity 13, member A
FOLR1 folate receptor 1 (adult)
FOXJ3 forkhead box J3
GDF15 growth differentiation factor 15
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GRWD1 glutamate-rich WD repeat containing 1
HEATR1 HEAT repeat containing 1
HOPX HOP homeobox
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
LAMP5 lysosomal-associated membrane protein family, member 5
MCAM melanoma cell adhesion molecule
MMP12 matrix metallopeptidase 12
MRPL19 mitochondrial ribosomal protein L19
MRPS2 mitochondrial ribosomal protein S2
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSBPL10 oxysterol binding protein-like 10
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PON2 paraoxonase 2
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRR15L proline rich 15-like
PTGDS prostaglandin D2 synthase 21kDa (brain)
QPRT quinolinate phosphoribosyltransferase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPON1 spondin 1, extracellular matrix protein
TBC1D4 TBC1 domain family, member 4
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TSPAN13 tetraspanin 13
TTC39A tetratricopeptide repeat domain 39A
TYMS thymidylate synthetase
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)