BRD-A25687296_EMETINE_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

281 genes differentially expressed following the BRD-A25687296_EMETINE_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM8 ADAM metallopeptidase domain 8
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AMOTL2 angiomotin like 2
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ATF3 activating transcription factor 3
BCL3 B-cell CLL/lymphoma 3
BHLHE41 basic helix-loop-helix family, member e41
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRD8 bromodomain containing 8
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP14 dual specificity phosphatase 14
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR2 early growth response 2
EHD1 EH-domain containing 1
ERCC5 excision repair cross-complementation group 5
EREG epiregulin
F5 coagulation factor V (proaccelerin, labile factor)
FBXO38 F-box protein 38
FDXR ferredoxin reductase
FHL2 four and a half LIM domains 2
FNBP4 formin binding protein 4
FOSL2 FOS-like antigen 2
G0S2 G0/G1 switch 2
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GRB14 growth factor receptor-bound protein 14
GRIA2 glutamate receptor, ionotropic, AMPA 2
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
H2BFS H2B histone family, member S (pseudogene)
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HOPX HOP homeobox
HP haptoglobin
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL6 interleukin 6
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF10 Kruppel-like factor 10
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT7 keratin 7, type II
KYNU kynureninase
LIF leukemia inhibitory factor
LIMCH1 LIM and calponin homology domains 1
LIPG lipase, endothelial
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINJ1 ninjurin 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDE4B phosphodiesterase 4B, cAMP-specific
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POMZP3 POM121 and ZP3 fusion
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RIPK2 receptor-interacting serine-threonine kinase 2
RND1 Rho family GTPase 1
RNF167 ring finger protein 167
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SIRT1 sirtuin 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBC1D31 TBC1 domain family, member 31
TGIF1 TGFB-induced factor homeobox 1
THADA thyroid adenoma associated
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TUFT1 tuftelin 1
UBAP1 ubiquitin associated protein 1
UBAP2 ubiquitin associated protein 2
WSB1 WD repeat and SOCS box containing 1
ZC3H12A zinc finger CCCH-type containing 12A
ZNF140 zinc finger protein 140
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ADA adenosine deaminase
ADIRF adipogenesis regulatory factor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AIDA axin interactor, dorsalization associated
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BACE2 beta-site APP-cleaving enzyme 2
BLCAP bladder cancer associated protein
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA12 carbonic anhydrase XII
CACYBP calcyclin binding protein
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CBR3 carbonyl reductase 3
CCND1 cyclin D1
CD99 CD99 molecule
CDC25A cell division cycle 25A
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CKLF chemokine-like factor
CLCA4 chloride channel accessory 4
CLIC4 chloride intracellular channel 4
CST3 cystatin C
CTSZ cathepsin Z
DICER1 dicer 1, ribonuclease type III
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
ECI2 enoyl-CoA delta isomerase 2
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EHBP1L1 EH domain binding protein 1-like 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELOVL5 ELOVL fatty acid elongase 5
EMP2 epithelial membrane protein 2
ENDOD1 endonuclease domain containing 1
ENO1 enolase 1, (alpha)
ERLIN1 ER lipid raft associated 1
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GLUL glutamate-ammonia ligase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPNMB glycoprotein (transmembrane) nmb
GUK1 guanylate kinase 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HBB hemoglobin, beta
HOXB7 homeobox B7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
LEF1 lymphoid enhancer-binding factor 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LPGAT1 lysophosphatidylglycerol acyltransferase 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL9 methyltransferase like 9
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MLEC malectin
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NEK7 NIMA-related kinase 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
OAT ornithine aminotransferase
PANK3 pantothenate kinase 3
PDLIM1 PDZ and LIM domain 1
PGK1 phosphoglycerate kinase 1
PMP22 peripheral myelin protein 22
RAB4A RAB4A, member RAS oncogene family
RCN2 reticulocalbin 2, EF-hand calcium binding domain
REG3A regenerating islet-derived 3 alpha
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEPT11 septin 11
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SST somatostatin
SYPL1 synaptophysin-like 1
TMEM47 transmembrane protein 47
TMX1 thioredoxin-related transmembrane protein 1
TOX thymocyte selection-associated high mobility group box
TRAF5 TNF receptor-associated factor 5
TSPAN13 tetraspanin 13
TUBA1A tubulin, alpha 1a
TUBB6 tubulin, beta 6 class V
TWF1 twinfilin actin binding protein 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone
WSB2 WD repeat and SOCS box containing 2
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta