BRD-A25687296_EMETINE_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

272 genes differentially expressed following the BRD-A25687296_EMETINE_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ANXA3 annexin A3
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCAS2 breast carcinoma amplified sequence 2
BCL3 B-cell CLL/lymphoma 3
BCL7B B-cell CLL/lymphoma 7B
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BRD2 bromodomain containing 2
BTG3 BTG family, member 3
C7 complement component 7
CCNL1 cyclin L1
CDKN2AIP CDKN2A interacting protein
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COMP cartilage oligomeric matrix protein
COQ10B coenzyme Q10 homolog B (S. cerevisiae)
CSRP2 cysteine and glycine-rich protein 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DHRS2 dehydrogenase/reductase (SDR family) member 2
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
ECD ecdysoneless homolog (Drosophila)
EGR1 early growth response 1
ELF1 E74-like factor 1 (ets domain transcription factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM13A family with sequence similarity 13, member A
FAM63A family with sequence similarity 63, member A
FHL2 four and a half LIM domains 2
FKBP14 FK506 binding protein 14, 22 kDa
FLRT3 fibronectin leucine rich transmembrane protein 3
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2B general transcription factor IIB
GTPBP8 GTP-binding protein 8 (putative)
H2BFS H2B histone family, member S (pseudogene)
H3F3B H3 histone, family 3B (H3.3B)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA14 heat shock 70kDa protein 14
ICA1 islet cell autoantigen 1, 69kDa
IER2 immediate early response 2
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ING3 inhibitor of growth family, member 3
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5A lysine (K)-specific demethylase 5A
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIN Kin17 DNA and RNA binding protein
KLF5 Kruppel-like factor 5 (intestinal)
KYNU kynureninase
LIMA1 LIM domain and actin binding 1
MCL1 myeloid cell leukemia 1
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MOK MOK protein kinase
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NET1 neuroepithelial cell transforming 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFYC nuclear transcription factor Y, gamma
NMB neuromedin B
NRIP1 nuclear receptor interacting protein 1
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PHF21A PHD finger protein 21A
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKN2 protein kinase N2
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS2 protease, serine, 2 (trypsin 2)
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAE1 ribonucleic acid export 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM39 RNA binding motif protein 39
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSRC2 arginine/serine-rich coiled-coil 2
SKAP2 src kinase associated phosphoprotein 2
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SNX11 sorting nexin 11
SRRM2 serine/arginine repetitive matrix 2
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STX1A syntaxin 1A (brain)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TERF2IP telomeric repeat binding factor 2, interacting protein
TESC tescalcin
TEX10 testis expressed 10
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THUMPD2 THUMP domain containing 2
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIK TRAF2 and NCK interacting kinase
TRA2B transformer 2 beta homolog (Drosophila)
TRH thyrotropin-releasing hormone
TRIT1 tRNA isopentenyltransferase 1
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
U2SURP U2 snRNP-associated SURP domain containing
UBAP1 ubiquitin associated protein 1
UBAP2 ubiquitin associated protein 2
UIMC1 ubiquitin interaction motif containing 1
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP3 ubiquitin specific peptidase 3
VCAM1 vascular cell adhesion molecule 1
YTHDC1 YTH domain containing 1
ZNF211 zinc finger protein 211
ZNF222 zinc finger protein 222
ZNF226 zinc finger protein 226
ZNF451 zinc finger protein 451
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAM9 ADAM metallopeptidase domain 9
AIDA axin interactor, dorsalization associated
AIM1 absent in melanoma 1
ALB albumin
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
C6ORF62 chromosome 6 open reading frame 62
CALU calumenin
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CD9 CD9 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CLCA4 chloride channel accessory 4
CLIC4 chloride intracellular channel 4
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
EFCAB14 EF-hand calcium binding domain 14
ENO1 enolase 1, (alpha)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FABP1 fatty acid binding protein 1, liver
FAM3C family with sequence similarity 3, member C
FBXL7 F-box and leucine-rich repeat protein 7
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FKBP11 FK506 binding protein 11, 19 kDa
FSTL1 follistatin-like 1
GLUL glutamate-ammonia ligase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMGB3 high mobility group box 3
HMGN4 high mobility group nucleosomal binding domain 4
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IGL immunoglobulin lambda locus
IL32 interleukin 32
INSIG1 insulin induced gene 1
IRAK1 interleukin-1 receptor-associated kinase 1
JCHAIN joining chain of multimeric IgA and IgM
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP1 lysosomal-associated membrane protein 1
LBR lamin B receptor
LUM lumican
MAN2A1 mannosidase, alpha, class 2A, member 1
MAT2A methionine adenosyltransferase II, alpha
METTL9 methyltransferase like 9
MEX3D mex-3 RNA binding family member D
MLEC malectin
MME membrane metallo-endopeptidase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO1D myosin ID
NEFH neurofilament, heavy polypeptide
NID1 nidogen 1
NMU neuromedin U
NTAN1 N-terminal asparagine amidase
P4HB prolyl 4-hydroxylase, beta polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4A phosphodiesterase 4A, cAMP-specific
PGK1 phosphoglycerate kinase 1
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PSAT1 phosphoserine aminotransferase 1
QARS glutaminyl-tRNA synthetase
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SDC2 syndecan 2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNN stannin
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPON2 spondin 2, extracellular matrix protein
TCF4 transcription factor 4
TFDP1 transcription factor Dp-1
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TMX1 thioredoxin-related transmembrane protein 1
TPBG trophoblast glycoprotein
TPST2 tyrosylprotein sulfotransferase 2
TSKU tsukushi, small leucine rich proteoglycan
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXN thioredoxin
UGP2 UDP-glucose pyrophosphorylase 2
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
ZIC1 Zic family member 1