BRD-A25687296_EMETINE_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

243 genes differentially expressed following the BRD-A25687296_EMETINE_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARID4B AT rich interactive domain 4B (RBP1-like)
BAMBI BMP and activin membrane-bound inhibitor
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BPTF bromodomain PHD finger transcription factor
C1ORF106 chromosome 1 open reading frame 106
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD24 CD24 molecule
CD9 CD9 molecule
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
CLU clusterin
COG4 component of oligomeric golgi complex 4
CSF1 colony stimulating factor 1 (macrophage)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSS cathepsin S
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYR61 cysteine-rich, angiogenic inducer, 61
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
FMR1 fragile X mental retardation 1
FOXO1 forkhead box O1
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GSE1 Gse1 coiled-coil protein
HES1 hes family bHLH transcription factor 1
HIST1H4C histone cluster 1, H4c
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IGHMBP2 immunoglobulin mu binding protein 2
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
ING3 inhibitor of growth family, member 3
IRF1 interferon regulatory factor 1
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM6A lysine (K)-specific demethylase 6A
KLF10 Kruppel-like factor 10
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRCC1 lysine-rich coiled-coil 1
KRT15 keratin 15, type I
KRT7 keratin 7, type II
KYNU kynureninase
LRRC40 leucine rich repeat containing 40
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MARCKS myristoylated alanine-rich protein kinase C substrate
MED13 mediator complex subunit 13
MTF2 metal response element binding transcription factor 2
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OPTN optineurin
PDGFA platelet-derived growth factor alpha polypeptide
PDGFRL platelet-derived growth factor receptor-like
PELI1 pellino E3 ubiquitin protein ligase 1
PER2 period circadian clock 2
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PNMA2 paraneoplastic Ma antigen 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTBP2 polypyrimidine tract binding protein 2
RAP1GAP RAP1 GTPase activating protein
RCOR3 REST corepressor 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RIOK3 RIO kinase 3
RLF rearranged L-myc fusion
RSRC2 arginine/serine-rich coiled-coil 2
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFRP1 secreted frizzled-related protein 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOBP sine oculis binding protein homolog (Drosophila)
SPATA5L1 spermatogenesis associated 5-like 1
SRSF11 serine/arginine-rich splicing factor 11
STAP2 signal transducing adaptor family member 2
SULF1 sulfatase 1
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TF transferrin
TKTL1 transketolase-like 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRAF1 TNF receptor-associated factor 1
TXNL4B thioredoxin-like 4B
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
UPP1 uridine phosphorylase 1
XIST X inactive specific transcript (non-protein coding)
YTHDC1 YTH domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1

decreased expression

Symbol Name
ADGRA3 adhesion G protein-coupled receptor A3
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
B3GNT1
C6ORF62 chromosome 6 open reading frame 62
CALU calumenin
CANX calnexin
CCDC6 coiled-coil domain containing 6
CCNG1 cyclin G1
CD99 CD99 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL3A1 collagen, type III, alpha 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DBN1 drebrin 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTT DNA nucleotidylexotransferase
DPP4 dipeptidyl-peptidase 4
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EMP2 epithelial membrane protein 2
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
GDE1 glycerophosphodiester phosphodiesterase 1
GLB1L2 galactosidase, beta 1-like 2
GLUD1 glutamate dehydrogenase 1
GLUD2 glutamate dehydrogenase 2
GLUL glutamate-ammonia ligase
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HBB hemoglobin, beta
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI6 interferon, alpha-inducible protein 6
IFITM3 interferon induced transmembrane protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB1BP1 integrin beta 1 binding protein 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0100 KIAA0100
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
MAZ MYC-associated zinc finger protein (purine-binding transcription factor)
METTL9 methyltransferase like 9
MLEC malectin
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MNDA myeloid cell nuclear differentiation antigen
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
NQO1 NAD(P)H dehydrogenase, quinone 1
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PGK1 phosphoglycerate kinase 1
PIR pirin (iron-binding nuclear protein)
PLK1 polo-like kinase 1
PRDX4 peroxiredoxin 4
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTDSS1 phosphatidylserine synthase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RAP2A RAP2A, member of RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBPMS RNA binding protein with multiple splicing
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPS11 ribosomal protein S11
SAMM50 SAMM50 sorting and assembly machinery component
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SDC2 syndecan 2
SFN stratifin
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STK24 serine/threonine kinase 24
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
SYBU syntabulin (syntaxin-interacting)
TBC1D16 TBC1 domain family, member 16
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TPD52L1 tumor protein D52-like 1
TPM4 tropomyosin 4
TSPAN13 tetraspanin 13
TTC3 tetratricopeptide repeat domain 3
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TUSC3 tumor suppressor candidate 3
TXNRD1 thioredoxin reductase 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
VAT1 vesicle amine transport 1
VDAC1 voltage-dependent anion channel 1