BRD-A25687296_EMETINE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

319 genes differentially expressed following the BRD-A25687296_EMETINE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
ARID4B AT rich interactive domain 4B (RBP1-like)
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF3 activating transcription factor 3
ATF6 activating transcription factor 6
ATF7IP activating transcription factor 7 interacting protein
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BST2 bone marrow stromal cell antigen 2
BTG2 BTG family, member 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
ECD ecdysoneless homolog (Drosophila)
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
FAM13A family with sequence similarity 13, member A
FLRT3 fibronectin leucine rich transmembrane protein 3
FNBP4 formin binding protein 4
FNDC3B fibronectin type III domain containing 3B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
HDAC9 histone deacetylase 9
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRF1 interferon regulatory factor 1
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM3A lysine (K)-specific demethylase 3A
KDM5A lysine (K)-specific demethylase 5A
KDM5B lysine (K)-specific demethylase 5B
KIAA0753 KIAA0753
KIAA0907 KIAA0907
KIAA1033 KIAA1033
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LIPG lipase, endothelial
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAMLD1 mastermind-like domain containing 1
MCL1 myeloid cell leukemia 1
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIL3 nuclear factor, interleukin 3 regulated
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
ODC1 ornithine decarboxylase 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PALLD palladin, cytoskeletal associated protein
PDGFC platelet derived growth factor C
PEG3 paternally expressed 3
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB4 phospholipase C, beta 4
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRRC2C proline-rich coiled-coil 2C
PSME4 proteasome (prosome, macropain) activator subunit 4
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RBM34 RNA binding motif protein 34
RCOR3 REST corepressor 3
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RSF1 remodeling and spacing factor 1
RSRC2 arginine/serine-rich coiled-coil 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK3 SIK family kinase 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPG20 spastic paraplegia 20 (Troyer syndrome)
SRRM2 serine/arginine repetitive matrix 2
SRSF7 serine/arginine-rich splicing factor 7
SVIL supervillin
TACSTD2 tumor-associated calcium signal transducer 2
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TBX3 T-box 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TG thyroglobulin
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TNIP1 TNFAIP3 interacting protein 1
TP53BP1 tumor protein p53 binding protein 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D1 TSC22 domain family, member 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
USP47 ubiquitin specific peptidase 47
UVRAG UV radiation resistance associated
WSB1 WD repeat and SOCS box containing 1
YY1AP1 YY1 associated protein 1
ZC3H12A zinc finger CCCH-type containing 12A
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274
ZNF767P zinc finger family member 767, pseudogene

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADIRF adipogenesis regulatory factor
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD46 ankyrin repeat domain 46
APOD apolipoprotein D
ARL4C ADP-ribosylation factor-like 4C
ARL5A ADP-ribosylation factor-like 5A
ARPP19 cAMP-regulated phosphoprotein, 19kDa
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BIN1 bridging integrator 1
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C14ORF132 chromosome 14 open reading frame 132
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CANT1 calcium activated nucleotidase 1
CCL8 chemokine (C-C motif) ligand 8
CCND1 cyclin D1
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CERK ceramide kinase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLGN calmegin
COX11 COX11 cytochrome c oxidase copper chaperone
CPT1A carnitine palmitoyltransferase 1A (liver)
CTBP1 C-terminal binding protein 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCK deoxycytidine kinase
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EMP2 epithelial membrane protein 2
ENO1 enolase 1, (alpha)
ETV5 ets variant 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR3 fibroblast growth factor receptor 3
GCLM glutamate-cysteine ligase, modifier subunit
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX2 glutathione peroxidase 2
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HEBP2 heme binding protein 2
HMGA2 high mobility group AT-hook 2
HMGB3 high mobility group box 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LAPTM4B lysosomal protein transmembrane 4 beta
LASP1 LIM and SH3 protein 1
LBH limb bud and heart development
LMO2 LIM domain only 2 (rhombotin-like 1)
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAT2A methionine adenosyltransferase II, alpha
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
MME membrane metallo-endopeptidase
MPZL1 myelin protein zero-like 1
MXRA7 matrix-remodelling associated 7
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NT5E 5'-nucleotidase, ecto (CD73)
P4HB prolyl 4-hydroxylase, beta polypeptide
PAMR1 peptidase domain containing associated with muscle regeneration 1
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PSAT1 phosphoserine aminotransferase 1
PSCA prostate stem cell antigen
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB27A RAB27A, member RAS oncogene family
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
S100P S100 calcium binding protein P
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SET SET nuclear proto-oncogene
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SNN stannin
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SRM spermidine synthase
SST somatostatin
STARD7 StAR-related lipid transfer (START) domain containing 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
STOM stomatin
SUB1 SUB1 homolog (S. cerevisiae)
SYNGR2 synaptogyrin 2
TBC1D16 TBC1 domain family, member 16
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TMCO3 transmembrane and coiled-coil domains 3
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM14A transmembrane protein 14A
TMX1 thioredoxin-related transmembrane protein 1
TPBG trophoblast glycoprotein
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
TXN thioredoxin
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP3 vesicle-associated membrane protein 3
WIF1 WNT inhibitory factor 1
WRB tryptophan rich basic protein
WSB2 WD repeat and SOCS box containing 2
XPOT exportin, tRNA
ZC3HAV1 zinc finger CCCH-type, antiviral 1