BRD-A25687296_EMETINE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

360 genes differentially expressed following the BRD-A25687296_EMETINE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATF3 activating transcription factor 3
ATF6 activating transcription factor 6
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BMP7 bone morphogenetic protein 7
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C9ORF3 chromosome 9 open reading frame 3
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHMP4A charged multivesicular body protein 4A
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COL11A1 collagen, type XI, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAPK3 death-associated protein kinase 3
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DMTF1 cyclin D binding myb-like transcription factor 1
DMXL2 Dmx-like 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DPYSL3 dihydropyrimidinase-like 3
DUSP8 dual specificity phosphatase 8
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EHD1 EH-domain containing 1
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FBXL12 F-box and leucine-rich repeat protein 12
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNAS GNAS complex locus
GREM1 gremlin 1, DAN family BMP antagonist
H1F0 H1 histone family, member 0
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BG histone cluster 1, H2bg
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
ILK integrin-linked kinase
ISG20 interferon stimulated exonuclease gene 20kDa
JMJD1C jumonji domain containing 1C
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KDM3A lysine (K)-specific demethylase 3A
KDM5B lysine (K)-specific demethylase 5B
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA1033 KIAA1033
KLF6 Kruppel-like factor 6
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT15 keratin 15, type I
KYNU kynureninase
LGALS8 lectin, galactoside-binding, soluble, 8
LMO3 LIM domain only 3 (rhombotin-like 2)
LOC81691 exonuclease NEF-sp
LPXN leupaxin
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
NCAM1 neural cell adhesion molecule 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NXF1 nuclear RNA export factor 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP8 poly (ADP-ribose) polymerase family, member 8
PDGFC platelet derived growth factor C
PER1 period circadian clock 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PILRB paired immunoglobin-like type 2 receptor beta
POLI polymerase (DNA directed) iota
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS21 protease, serine, 21 (testisin)
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
QKI QKI, KH domain containing, RNA binding
RAD9A RAD9 homolog A (S. pombe)
RAP1GAP RAP1 GTPase activating protein
RBKS ribokinase
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RIT1 Ras-like without CAAX 1
RLF rearranged L-myc fusion
RNF114 ring finger protein 114
RRAGD Ras-related GTP binding D
RSRC2 arginine/serine-rich coiled-coil 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP4 secreted frizzled-related protein 4
SIK3 SIK family kinase 3
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPAG9 sperm associated antigen 9
SVIL supervillin
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBC1D15 TBC1 domain family, member 15
TG thyroglobulin
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIK TRAF2 and NCK interacting kinase
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TUFT1 tuftelin 1
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP15 ubiquitin specific peptidase 15
WBP4 WW domain binding protein 4
YTHDC1 YTH domain containing 1
ZBTB43 zinc finger and BTB domain containing 43
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274
ZNF451 zinc finger protein 451
ZNF804A zinc finger protein 804A

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
APOL1 apolipoprotein L, 1
ARL4C ADP-ribosylation factor-like 4C
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BIN1 bridging integrator 1
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA12 carbonic anhydrase XII
CALU calumenin
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CBR1 carbonyl reductase 1
CCND3 cyclin D3
CD14 CD14 molecule
CD163 CD163 molecule
CD200 CD200 molecule
CD99 CD99 molecule
CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKLF chemokine-like factor
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CPNE3 copine III
CPOX coproporphyrinogen oxidase
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CTBP1 C-terminal binding protein 1
CTSL cathepsin L
CYBA cytochrome b-245, alpha polypeptide
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DCK deoxycytidine kinase
DCTPP1 dCTP pyrophosphatase 1
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPYSL2 dihydropyrimidinase-like 2
DUSP4 dual specificity phosphatase 4
ECI2 enoyl-CoA delta isomerase 2
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FCGBP Fc fragment of IgG binding protein
FGFR3 fibroblast growth factor receptor 3
FSTL1 follistatin-like 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLO1 glyoxalase I
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPI glucose-6-phosphate isomerase
GRSF1 G-rich RNA sequence binding factor 1
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HELLS helicase, lymphoid-specific
HMGB3 high mobility group box 3
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICMT isoprenylcysteine carboxyl methyltransferase
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDO1 indoleamine 2,3-dioxygenase 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGFBP7 insulin-like growth factor binding protein 7
IGLL1 immunoglobulin lambda-like polypeptide 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JADE2 jade family PHD finger 2
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
KCTD12 potassium channel tetramerization domain containing 12
KIAA0100 KIAA0100
KIAA0101 KIAA0101
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LAPTM5 lysosomal protein transmembrane 5
LBH limb bud and heart development
LBR lamin B receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LOC100505650 uncharacterized LOC100505650
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LY6E lymphocyte antigen 6 complex, locus E
LYPLA1 lysophospholipase I
MAP2K6 mitogen-activated protein kinase kinase 6
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MLEC malectin
MPZL1 myelin protein zero-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
MYD88 myeloid differentiation primary response 88
MYH10 myosin, heavy chain 10, non-muscle
NCK2 NCK adaptor protein 2
NDRG2 NDRG family member 2
NIT2 nitrilase family, member 2
NNMT nicotinamide N-methyltransferase
NPDC1 neural proliferation, differentiation and control, 1
NPY1R neuropeptide Y receptor Y1
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUP210 nucleoporin 210kDa
NUP43 nucleoporin 43kDa
P4HB prolyl 4-hydroxylase, beta polypeptide
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PI3 peptidase inhibitor 3, skin-derived
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLAT plasminogen activator, tissue
PLBD1 phospholipase B domain containing 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRDX4 peroxiredoxin 4
PROM1 prominin 1
PSAT1 phosphoserine aminotransferase 1
PTDSS1 phosphatidylserine synthase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PXDN peroxidasin
RAB15 RAB15, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RPA1 replication protein A1, 70kDa
RRM2 ribonucleotide reductase M2
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEPP1 selenoprotein P, plasma, 1
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC46A3 solute carrier family 46, member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SNX10 sorting nexin 10
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPON1 spondin 1, extracellular matrix protein
SPP1 secreted phosphoprotein 1
SSR1 signal sequence receptor, alpha
STARD7 StAR-related lipid transfer (START) domain containing 7
SUMO3 small ubiquitin-like modifier 3
TBC1D16 TBC1 domain family, member 16
TBC1D4 TBC1 domain family, member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIMELESS timeless circadian clock
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TMPO thymopoietin
TMX1 thioredoxin-related transmembrane protein 1
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TPBG trophoblast glycoprotein
TPD52L1 tumor protein D52-like 1
TRIB2 tribbles pseudokinase 2
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TXN thioredoxin
TYMS thymidylate synthetase
UBL4A ubiquitin-like 4A
UGCG UDP-glucose ceramide glucosyltransferase
UNG uracil-DNA glycosylase
VANGL1 VANGL planar cell polarity protein 1
VDAC1 voltage-dependent anion channel 1
XPOT exportin, tRNA