BRD-A25687296_EMETINE_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

344 genes differentially expressed following the BRD-A25687296_EMETINE_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AMOTL2 angiomotin like 2
APOLD1 apolipoprotein L domain containing 1
AQP1 aquaporin 1 (Colton blood group)
ARHGAP29 Rho GTPase activating protein 29
ATAD2 ATPase family, AAA domain containing 2
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BLM Bloom syndrome, RecQ helicase-like
BRD8 bromodomain containing 8
C10ORF10 chromosome 10 open reading frame 10
CADM1 cell adhesion molecule 1
CCNL1 cyclin L1
CCP110 centriolar coiled coil protein 110kDa
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CDC7 cell division cycle 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2AIP CDKN2A interacting protein
CENPU centromere protein U
CEP57 centrosomal protein 57kDa
CHEK1 checkpoint kinase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COL11A1 collagen, type XI, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DMTF1 cyclin D binding myb-like transcription factor 1
DNMBP dynamin binding protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
DUSP6 dual specificity phosphatase 6
E2F2 E2F transcription factor 2
EDN1 endothelin 1
EFNA1 ephrin-A1
EGF epidermal growth factor
EGR1 early growth response 1
EGR2 early growth response 2
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
ERAP2 endoplasmic reticulum aminopeptidase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
EXOSC8 exosome component 8
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOXO1 forkhead box O1
FXYD2 FXYD domain containing ion transport regulator 2
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GATA6 GATA binding protein 6
GBP1 guanylate binding protein 1, interferon-inducible
GBP2 guanylate binding protein 2, interferon-inducible
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GSTM3 glutathione S-transferase mu 3 (brain)
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
H1F0 H1 histone family, member 0
H1FX H1 histone family, member X
H3F3B H3 histone, family 3B (H3.3B)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2BG histone cluster 1, H2bg
ICAM1 intercellular adhesion molecule 1
ICAM2 intercellular adhesion molecule 2
IER2 immediate early response 2
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5A lysine (K)-specific demethylase 5A
KDM5D lysine (K)-specific demethylase 5D
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KYNU kynureninase
LIMCH1 LIM and calponin homology domains 1
LIPG lipase, endothelial
LMO3 LIM domain only 3 (rhombotin-like 2)
LYST lysosomal trafficking regulator
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MET MET proto-oncogene, receptor tyrosine kinase
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
N4BP2L2 NEDD4 binding protein 2-like 2
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OASL 2'-5'-oligoadenylate synthetase-like
PALLD palladin, cytoskeletal associated protein
PAX8 paired box 8
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G16 phospholipase A2, group XVI
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSMC3IP PSMC3 interacting protein
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RAE1 ribonucleic acid export 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFC2 replication factor C (activator 1) 2, 40kDa
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RND1 Rho family GTPase 1
RPS4Y1 ribosomal protein S4, Y-linked 1
RSRC2 arginine/serine-rich coiled-coil 2
SAV1 salvador family WW domain containing protein 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIK3 SIK family kinase 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPINK1 serine peptidase inhibitor, Kazal type 1
SRRM2 serine/arginine repetitive matrix 2
SRSF11 serine/arginine-rich splicing factor 11
SRSF7 serine/arginine-rich splicing factor 7
STARD13 StAR-related lipid transfer (START) domain containing 13
STAT1 signal transducer and activator of transcription 1, 91kDa
STX1A syntaxin 1A (brain)
SULF1 sulfatase 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TDRD7 tudor domain containing 7
TEX10 testis expressed 10
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TIPIN TIMELESS interacting protein
TKTL1 transketolase-like 1
TM4SF1 transmembrane 4 L six family member 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIK TRAF2 and NCK interacting kinase
TNPO1 transportin 1
TRAF1 TNF receptor-associated factor 1
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TUFT1 tuftelin 1
U2SURP U2 snRNP-associated SURP domain containing
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
USP18 ubiquitin specific peptidase 18
WEE1 WEE1 G2 checkpoint kinase
YTHDC1 YTH domain containing 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF410 zinc finger protein 410
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADAM9 ADAM metallopeptidase domain 9
ADGRA3 adhesion G protein-coupled receptor A3
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AMD1 adenosylmethionine decarboxylase 1
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1GALT1C1 C1GALT1-specific chaperone 1
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CBR3 carbonyl reductase 3
CBS cystathionine-beta-synthase
CD14 CD14 molecule
CD164 CD164 molecule, sialomucin
CD46 CD46 molecule, complement regulatory protein
CDK19 cyclin-dependent kinase 19
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CKAP4 cytoskeleton-associated protein 4
CLCA4 chloride channel accessory 4
CLDN7 claudin 7
CLIC1 chloride intracellular channel 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CSTB cystatin B (stefin B)
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DBN1 drebrin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNASE1L1 deoxyribonuclease I-like 1
DPYSL2 dihydropyrimidinase-like 2
DTX4 deltex 4, E3 ubiquitin ligase
DYNLL1 dynein, light chain, LC8-type 1
EFCAB14 EF-hand calcium binding domain 14
EMP2 epithelial membrane protein 2
ENO2 enolase 2 (gamma, neuronal)
EYA2 EYA transcriptional coactivator and phosphatase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM3C family with sequence similarity 3, member C
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FCGBP Fc fragment of IgG binding protein
FKBP9 FK506 binding protein 9, 63 kDa
GDI2 GDP dissociation inhibitor 2
GLIPR1 GLI pathogenesis-related 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GREM1 gremlin 1, DAN family BMP antagonist
GSTA1 glutathione S-transferase alpha 1
HEBP2 heme binding protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGB3 high mobility group box 3
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HOXA10 homeobox A10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPE1 heat shock 10kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INSIG1 insulin induced gene 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JCHAIN joining chain of multimeric IgA and IgM
KIAA0100 KIAA0100
LAPTM4B lysosomal protein transmembrane 4 beta
LBH limb bud and heart development
LIPA lipase A, lysosomal acid, cholesterol esterase
LPCAT4 lysophosphatidylcholine acyltransferase 4
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MAGED1 melanoma antigen family D1
MAT2A methionine adenosyltransferase II, alpha
METTL9 methyltransferase like 9
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MMP10 matrix metallopeptidase 10
MPZL1 myelin protein zero-like 1
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
NEFH neurofilament, heavy polypeptide
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F6 nuclear receptor subfamily 2, group F, member 6
OAT ornithine aminotransferase
OLFML3 olfactomedin-like 3
PAM peptidylglycine alpha-amidating monooxygenase
PDIA6 protein disulfide isomerase family A, member 6
PDLIM2 PDZ and LIM domain 2 (mystique)
PDZD8 PDZ domain containing 8
PGK1 phosphoglycerate kinase 1
PGRMC1 progesterone receptor membrane component 1
PI3 peptidase inhibitor 3, skin-derived
PLSCR3 phospholipid scramblase 3
PLTP phospholipid transfer protein
POU2AF1 POU class 2 associating factor 1
PRDX4 peroxiredoxin 4
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE4 ribonuclease, RNase A family, 4
RNASET2 ribonuclease T2
RPS11 ribosomal protein S11
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SDC2 syndecan 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELENBP1 selenium binding protein 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SEPP1 selenoprotein P, plasma, 1
SEPT11 septin 11
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SMAGP small cell adhesion glycoprotein
SMYD2 SET and MYND domain containing 2
SNN stannin
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SPON2 spondin 2, extracellular matrix protein
SPTSSA serine palmitoyltransferase, small subunit A
SST somatostatin
STARD7 StAR-related lipid transfer (START) domain containing 7
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TBC1D16 TBC1 domain family, member 16
TBCB tubulin folding cofactor B
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM109 transmembrane protein 109
TMEM14A transmembrane protein 14A
TMEM2 transmembrane protein 2
TNS1 tensin 1
TPST2 tyrosylprotein sulfotransferase 2
TSPAN13 tetraspanin 13
TSPYL1 TSPY-like 1
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUSC3 tumor suppressor candidate 3
TWF1 twinfilin actin binding protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WSB2 WD repeat and SOCS box containing 2
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)