BRD-A25687296_EMETINE_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

157 genes differentially expressed following the BRD-A25687296_EMETINE_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDKN2AIP CDKN2A interacting protein
CGA glycoprotein hormones, alpha polypeptide
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EGR3 early growth response 3
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM179B family with sequence similarity 179, member B
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GSTM3 glutathione S-transferase mu 3 (brain)
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BC histone cluster 1, H2bc
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H4H histone cluster 1, H4h
IER2 immediate early response 2
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFRD1 interferon-related developmental regulator 1
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KIAA0753 KIAA0753
MCL1 myeloid cell leukemia 1
MTF2 metal response element binding transcription factor 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGRN neugrin, neurite outgrowth associated
NLRP2 NLR family, pyrin domain containing 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
PMM2 phosphomannomutase 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
SCYL3 SCY1-like 3 (S. cerevisiae)
SLC16A6 solute carrier family 16, member 6
SLC38A1 solute carrier family 38, member 1
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX9 SRY (sex determining region Y)-box 9
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TSC22D1 TSC22 domain family, member 1
XIST X inactive specific transcript (non-protein coding)
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACOT7 acyl-CoA thioesterase 7
ADIRF adipogenesis regulatory factor
APOD apolipoprotein D
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BGN biglycan
C1QB complement component 1, q subcomponent, B chain
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CCND1 cyclin D1
CCNF cyclin F
CD163 CD163 molecule
CERK ceramide kinase
COL4A1 collagen, type IV, alpha 1
CPT1A carnitine palmitoyltransferase 1A (liver)
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CXCL14 chemokine (C-X-C motif) ligand 14
CYCS cytochrome c, somatic
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFB1 defensin, beta 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL2 dihydropyrimidinase-like 2
ENO2 enolase 2 (gamma, neuronal)
FKBP9 FK506 binding protein 9, 63 kDa
FSTL1 follistatin-like 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
HMGA2 high mobility group AT-hook 2
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
INSR insulin receptor
IQSEC1 IQ motif and Sec7 domain 1
KANK2 KN motif and ankyrin repeat domains 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
MAP1B microtubule-associated protein 1B
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MLEC malectin
MT1M metallothionein 1M
MTDH metadherin
MTSS1 metastasis suppressor 1
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PBK PDZ binding kinase
PIR pirin (iron-binding nuclear protein)
PSCA prostate stem cell antigen
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTX3 pentraxin 3, long
SEPT11 septin 11
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SNX6 sorting nexin 6
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
TBC1D16 TBC1 domain family, member 16
TFDP1 transcription factor Dp-1
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TSPYL5 TSPY-like 5
WSB2 WD repeat and SOCS box containing 2
ZIC1 Zic family member 1