BRD-A25687296_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

302 genes differentially expressed following the BRD-A25687296_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP8L A kinase (PRKA) anchor protein 8-like
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRD28 ankyrin repeat domain 28
AQP1 aquaporin 1 (Colton blood group)
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP15 Rho GTPase activating protein 15
ATG3 autophagy related 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
AZU1 azurocidin 1
BBX bobby sox homolog (Drosophila)
BPTF bromodomain PHD finger transcription factor
CAPN1 calpain 1, (mu/I) large subunit
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEP350 centrosomal protein 350kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLCA1 chloride channel accessory 1
CLEC2B C-type lectin domain family 2, member B
CLK4 CDC-like kinase 4
CLTB clathrin, light chain B
CNOT4 CCR4-NOT transcription complex, subunit 4
CTSG cathepsin G
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2
DNM3 dynamin 3
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
EPS8 epidermal growth factor receptor pathway substrate 8
EVI2A ecotropic viral integration site 2A
FOXO4 forkhead box O4
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLS glutaminase
GSE1 Gse1 coiled-coil protein
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
ICAM1 intercellular adhesion molecule 1
IFRD1 interferon-related developmental regulator 1
JMJD6 jumonji domain containing 6
KRT17 keratin 17, type I
KYNU kynureninase
LGALS4 lectin, galactoside-binding, soluble, 4
MAP2K5 mitogen-activated protein kinase kinase 5
MED13 mediator complex subunit 13
MEF2C myocyte enhancer factor 2C
MET MET proto-oncogene, receptor tyrosine kinase
MMP7 matrix metallopeptidase 7
MOK MOK protein kinase
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NET1 neuroepithelial cell transforming 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
OSBPL2 oxysterol binding protein-like 2
PCLO piccolo presynaptic cytomatrix protein
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PHIP pleckstrin homology domain interacting protein
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRRC2C proline-rich coiled-coil 2C
RABGAP1L RAB GTPase activating protein 1-like
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RB1CC1 RB1-inducible coiled-coil 1
RBBP6 retinoblastoma binding protein 6
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RIOK3 RIO kinase 3
SATB2 SATB homeobox 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SIK3 SIK family kinase 3
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPAG9 sperm associated antigen 9
SRRM2 serine/arginine repetitive matrix 2
ST7 suppression of tumorigenicity 7
SV2B synaptic vesicle glycoprotein 2B
SYNJ1 synaptojanin 1
SYT1 synaptotagmin I
TAOK3 TAO kinase 3
TERF2IP telomeric repeat binding factor 2, interacting protein
THUMPD2 THUMP domain containing 2
TKTL1 transketolase-like 1
TOMM34 translocase of outer mitochondrial membrane 34
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VNN1 vanin 1
VSNL1 visinin-like 1
WIF1 WNT inhibitory factor 1
WNK1 WNK lysine deficient protein kinase 1
YY1AP1 YY1 associated protein 1
ZC3H15 zinc finger CCCH-type containing 15
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
ADAM9 ADAM metallopeptidase domain 9
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK4 adenylate kinase 4
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARMT1 acidic residue methyltransferase 1
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AUTS2 autism susceptibility candidate 2
BST2 bone marrow stromal cell antigen 2
C14ORF1 chromosome 14 open reading frame 1
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALU calumenin
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CD81 CD81 molecule
CD99 CD99 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CETN2 centrin, EF-hand protein, 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DCTPP1 dCTP pyrophosphatase 1
DES desmin
DFNA5 deafness, autosomal dominant 5
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOCK4 dedicator of cytokinesis 4
EBP emopamil binding protein (sterol isomerase)
EFS embryonal Fyn-associated substrate
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
ENO2 enolase 2 (gamma, neuronal)
EPB41L3 erythrocyte membrane protein band 4.1-like 3
F2R coagulation factor II (thrombin) receptor
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GDF15 growth differentiation factor 15
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GNS glucosamine (N-acetyl)-6-sulfatase
GOLM1 golgi membrane protein 1
GPC4 glypican 4
GPNMB glycoprotein (transmembrane) nmb
GPR137B G protein-coupled receptor 137B
GPX1 glutathione peroxidase 1
GRAMD4 GRAM domain containing 4
GREM1 gremlin 1, DAN family BMP antagonist
H2AFV H2A histone family, member V
H2AFZ H2A histone family, member Z
HBB hemoglobin, beta
HCLS1 hematopoietic cell-specific Lyn substrate 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HILPDA hypoxia inducible lipid droplet-associated
HMGB3 high mobility group box 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HN1L hematological and neurological expressed 1-like
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP3 insulin-like growth factor binding protein 3
INSIG1 insulin induced gene 1
KIAA0101 KIAA0101
LBR lamin B receptor
LGMN legumain
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MAT2A methionine adenosyltransferase II, alpha
MCAM melanoma cell adhesion molecule
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MDK midkine (neurite growth-promoting factor 2)
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
MMP10 matrix metallopeptidase 10
MRPL12 mitochondrial ribosomal protein L12
MRPL57 mitochondrial ribosomal protein L57
MSH6 mutS homolog 6
MSMO1 methylsterol monooxygenase 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NAP1L1 nucleosome assembly protein 1-like 1
NCK2 NCK adaptor protein 2
NDN necdin, melanoma antigen (MAGE) family member
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUP210 nucleoporin 210kDa
NUP62 nucleoporin 62kDa
OAT ornithine aminotransferase
ODC1 ornithine decarboxylase 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PALLD palladin, cytoskeletal associated protein
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDIA4 protein disulfide isomerase family A, member 4
PDIA6 protein disulfide isomerase family A, member 6
PEBP1 phosphatidylethanolamine binding protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PRSS23 protease, serine, 23
PSAP prosaposin
PTGIS prostaglandin I2 (prostacyclin) synthase
PXMP2 peroxisomal membrane protein 2, 22kDa
RALGDS ral guanine nucleotide dissociation stimulator
RBBP4 retinoblastoma binding protein 4
RBP1 retinol binding protein 1, cellular
RHOBTB1 Rho-related BTB domain containing 1
RPA1 replication protein A1, 70kDa
RPL10 ribosomal protein L10
RPS11 ribosomal protein S11
RRM2 ribonucleotide reductase M2
SACS sacsin molecular chaperone
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SDF2L1 stromal cell-derived factor 2-like 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNN stannin
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SQLE squalene epoxidase
SRP9 signal recognition particle 9kDa
SRSF5 serine/arginine-rich splicing factor 5
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBL1X transducin (beta)-like 1X-linked
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TIMELESS timeless circadian clock
TMED9 transmembrane emp24 protein transport domain containing 9
TMEM230 transmembrane protein 230
TMEM97 transmembrane protein 97
TMSB15B thymosin beta 15B
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TSPAN13 tetraspanin 13
TSPAN6 tetraspanin 6
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNG uracil-DNA glycosylase
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
WWTR1 WW domain containing transcription regulator 1
ZBED1 zinc finger, BED-type containing 1
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF232 zinc finger protein 232
ZWINT ZW10 interacting kinetochore protein