BRD-A25687296_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

202 genes differentially expressed following the BRD-A25687296_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADM adrenomedullin
AGTR1 angiotensin II receptor, type 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ARHGAP29 Rho GTPase activating protein 29
ARID4A AT rich interactive domain 4A (RBP1-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
C10ORF10 chromosome 10 open reading frame 10
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CDK17 cyclin-dependent kinase 17
CDKN2AIP CDKN2A interacting protein
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
CLU clusterin
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CXCL2 chemokine (C-X-C motif) ligand 2
CYLD cylindromatosis (turban tumor syndrome)
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
FABP4 fatty acid binding protein 4, adipocyte
FNDC3B fibronectin type III domain containing 3B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPATCH8 G patch domain containing 8
GSE1 Gse1 coiled-coil protein
HES1 hes family bHLH transcription factor 1
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HPRT1 hypoxanthine phosphoribosyltransferase 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL32 interleukin 32
ING3 inhibitor of growth family, member 3
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KDM5D lysine (K)-specific demethylase 5D
KLF9 Kruppel-like factor 9
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MGLL monoglyceride lipase
MMP9 matrix metallopeptidase 9
MTSS1 metastasis suppressor 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NINJ1 ninjurin 1
NR1H3 nuclear receptor subfamily 1, group H, member 3
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OPTN optineurin
PCF11 PCF11 cleavage and polyadenylation factor subunit
PDE4B phosphodiesterase 4B, cAMP-specific
PDE9A phosphodiesterase 9A
PDGFA platelet-derived growth factor alpha polypeptide
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RAP1GAP RAP1 GTPase activating protein
RCOR3 REST corepressor 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFTN1 raftlin, lipid raft linker 1
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SDC4 syndecan 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SWAP70 SWAP switching B-cell complex 70kDa subunit
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNIP1 TNFAIP3 interacting protein 1
TP63 tumor protein p63
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
VCAM1 vascular cell adhesion molecule 1
ZCCHC8 zinc finger, CCHC domain containing 8
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
AHNAK2 AHNAK nucleoprotein 2
AKR1C2 aldo-keto reductase family 1, member C2
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
C14ORF132 chromosome 14 open reading frame 132
C5AR1 complement component 5a receptor 1
CALU calumenin
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CD99 CD99 molecule
CDC25B cell division cycle 25B
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CSRP1 cysteine and glycine-rich protein 1
DBN1 drebrin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLG5 discs, large homolog 5 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPT dermatopontin
DSTN destrin (actin depolymerizing factor)
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EMP1 epithelial membrane protein 1
EMP2 epithelial membrane protein 2
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FN1 fibronectin 1
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
KCTD12 potassium channel tetramerization domain containing 12
KIAA0100 KIAA0100
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
LYZ lysozyme
MAT2A methionine adenosyltransferase II, alpha
MFAP4 microfibrillar-associated protein 4
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MMP3 matrix metallopeptidase 3
MOCOS molybdenum cofactor sulfurase
MSX1 msh homeobox 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
OLFM4 olfactomedin 4
PFN2 profilin 2
PGK1 phosphoglycerate kinase 1
POU2AF1 POU class 2 associating factor 1
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RNASET2 ribonuclease T2
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPN2 ribophorin II
RPS11 ribosomal protein S11
S100A10 S100 calcium binding protein A10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPP1 selenoprotein P, plasma, 1
SET SET nuclear proto-oncogene
SFN stratifin
SFPQ splicing factor proline/glutamine-rich
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMYD2 SET and MYND domain containing 2
SOX4 SRY (sex determining region Y)-box 4
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SSR1 signal sequence receptor, alpha
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STS steroid sulfatase (microsomal), isozyme S
SYBU syntabulin (syntaxin-interacting)
TFDP1 transcription factor Dp-1
TGFBR3 transforming growth factor, beta receptor III
TIMP3 TIMP metallopeptidase inhibitor 3
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM164 transmembrane protein 164
TMEM2 transmembrane protein 2
TMEM97 transmembrane protein 97
TMSB15A thymosin beta 15a
TSPAN8 tetraspanin 8
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXN thioredoxin
UBE2S ubiquitin-conjugating enzyme E2S