BRD-A25687296_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

366 genes differentially expressed following the BRD-A25687296_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AGTR1 angiotensin II receptor, type 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
ALOX5 arachidonate 5-lipoxygenase
ANKRD12 ankyrin repeat domain 12
ARID4B AT rich interactive domain 4B (RBP1-like)
ATAD2B ATPase family, AAA domain containing 2B
ATF3 activating transcription factor 3
ATG12 autophagy related 12
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BAMBI BMP and activin membrane-bound inhibitor
BHLHE41 basic helix-loop-helix family, member e41
BIRC3 baculoviral IAP repeat containing 3
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL19 chemokine (C-C motif) ligand 19
CCL2 chemokine (C-C motif) ligand 2
CD24 CD24 molecule
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CENPE centromere protein E, 312kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CHN1 chimerin 1
CLC Charcot-Leyden crystal galectin
CLK4 CDC-like kinase 4
CLU clusterin
CNOT4 CCR4-NOT transcription complex, subunit 4
CPA3 carboxypeptidase A3 (mast cell)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLX2 distal-less homeobox 2
DUSP14 dual specificity phosphatase 14
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
FHL2 four and a half LIM domains 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GEM GTP binding protein overexpressed in skeletal muscle
GNPDA1 glucosamine-6-phosphate deaminase 1
GTF2B general transcription factor IIB
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa
H2BFS H2B histone family, member S (pseudogene)
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BI histone cluster 1, H2bi
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST1H4H histone cluster 1, H4h
HIST2H2BE histone cluster 2, H2be
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
ICAM1 intercellular adhesion molecule 1
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGKV1-5 immunoglobulin kappa variable 1-5
IL1B interleukin 1, beta
ING3 inhibitor of growth family, member 3
INTS6 integrator complex subunit 6
IRS2 insulin receptor substrate 2
JMJD6 jumonji domain containing 6
KIAA0907 KIAA0907
KIDINS220 kinase D-interacting substrate, 220kDa
KIF18A kinesin family member 18A
KLF10 Kruppel-like factor 10
KLF5 Kruppel-like factor 5 (intestinal)
KLK5 kallikrein-related peptidase 5
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT23 keratin 23, type I
KYNU kynureninase
LGALS4 lectin, galactoside-binding, soluble, 4
LGALS8 lectin, galactoside-binding, soluble, 8
LMO3 LIM domain only 3 (rhombotin-like 2)
LST1 leukocyte specific transcript 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MCOLN1 mucolipin 1
MED13 mediator complex subunit 13
MEF2C myocyte enhancer factor 2C
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MNAT1 MNAT CDK-activating kinase assembly factor 1
MTF2 metal response element binding transcription factor 2
NELL2 NEL-like 2 (chicken)
NFE2L2 nuclear factor, erythroid 2-like 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PEG10 paternally expressed 10
PER2 period circadian clock 2
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPARG peroxisome proliferator-activated receptor gamma
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTTG1 pituitary tumor-transforming 1
RAB29 RAB29, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBKS ribokinase
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
RPIA ribose 5-phosphate isomerase A
RRAGC Ras-related GTP binding C
RSRC2 arginine/serine-rich coiled-coil 2
RYBP RING1 and YY1 binding protein
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SCGB2A2 secretoglobin, family 2A, member 2
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SIK3 SIK family kinase 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
SSBP2 single-stranded DNA binding protein 2
STX1A syntaxin 1A (brain)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF12 transcription factor 12
TCL1A T-cell leukemia/lymphoma 1A
TDO2 tryptophan 2,3-dioxygenase
TEX10 testis expressed 10
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLK2 tousled-like kinase 2
TNPO1 transportin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53BP2 tumor protein p53 binding protein 2
TRBC1 T cell receptor beta constant 1
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
UBE2C ubiquitin-conjugating enzyme E2C
UPF3B UPF3 regulator of nonsense transcripts homolog B (yeast)
USP15 ubiquitin specific peptidase 15
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
YTHDC1 YTH domain containing 1
ZHX2 zinc fingers and homeoboxes 2
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ACAT1 acetyl-CoA acetyltransferase 1
ACLY ATP citrate lyase
ADAM9 ADAM metallopeptidase domain 9
AHNAK AHNAK nucleoprotein
AIDA axin interactor, dorsalization associated
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa
ASMTL acetylserotonin O-methyltransferase-like
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
B3GNT1
BGN biglycan
BLVRA biliverdin reductase A
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C2CD2 C2 calcium-dependent domain containing 2
CBR1 carbonyl reductase 1
CCDC92 coiled-coil domain containing 92
CCNG1 cyclin G1
CCNI cyclin I
CD46 CD46 molecule, complement regulatory protein
CETN2 centrin, EF-hand protein, 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKAP4 cytoskeleton-associated protein 4
COL6A1 collagen, type VI, alpha 1
CPM carboxypeptidase M
CRTAP cartilage associated protein
CRYZ crystallin, zeta (quinone reductase)
CTSL cathepsin L
CYB5R3 cytochrome b5 reductase 3
DDHD2 DDHD domain containing 2
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNASE1L1 deoxyribonuclease I-like 1
DOK4 docking protein 4
DPY19L1 dpy-19-like 1 (C. elegans)
DPYSL2 dihydropyrimidinase-like 2
ECI2 enoyl-CoA delta isomerase 2
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EFS embryonal Fyn-associated substrate
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ERLIN2 ER lipid raft associated 2
EYA2 EYA transcriptional coactivator and phosphatase 2
F2R coagulation factor II (thrombin) receptor
FADS1 fatty acid desaturase 1
FAM114A1 family with sequence similarity 114, member A1
FAM149A family with sequence similarity 149, member A
FAM57A family with sequence similarity 57, member A
FASN fatty acid synthase
FHL1 four and a half LIM domains 1
FKBP11 FK506 binding protein 11, 19 kDa
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FSTL1 follistatin-like 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GHR growth hormone receptor
GLO1 glyoxalase I
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAS GNAS complex locus
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GOLM1 golgi membrane protein 1
GPC1 glypican 1
GPC4 glypican 4
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GPX7 glutathione peroxidase 7
GSTP1 glutathione S-transferase pi 1
GYS1 glycogen synthase 1 (muscle)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HDLBP high density lipoprotein binding protein
HEBP2 heme binding protein 2
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA10 homeobox A10
HPRT1 hypoxanthine phosphoribosyltransferase 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL1R1 interleukin 1 receptor, type I
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD12 potassium channel tetramerization domain containing 12
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LMO2 LIM domain only 2 (rhombotin-like 1)
LOX lysyl oxidase
LPCAT1 lysophosphatidylcholine acyltransferase 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LYPLA1 lysophospholipase I
MAGED1 melanoma antigen family D1
MAGEH1 melanoma antigen family H1
MFSD10 major facilitator superfamily domain containing 10
MKNK2 MAP kinase interacting serine/threonine kinase 2
MLEC malectin
MPST mercaptopyruvate sulfurtransferase
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYCBP MYC binding protein
NAP1L1 nucleosome assembly protein 1-like 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NT5DC2 5'-nucleotidase domain containing 2
OAT ornithine aminotransferase
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
P4HB prolyl 4-hydroxylase, beta polypeptide
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCYOX1 prenylcysteine oxidase 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM2 PDZ and LIM domain 2 (mystique)
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PIR pirin (iron-binding nuclear protein)
PLAT plasminogen activator, tissue
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
PRAF2 PRA1 domain family, member 2
PRDX4 peroxiredoxin 4
PROM1 prominin 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTGIS prostaglandin I2 (prostacyclin) synthase
PYCR1 pyrroline-5-carboxylate reductase 1
RAB40B RAB40B, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBBP7 retinoblastoma binding protein 7
RNASET2 ribonuclease T2
RPL10 ribosomal protein L10
S100A10 S100 calcium binding protein A10
SCCPDH saccharopine dehydrogenase (putative)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPT10 septin 10
SEPT11 septin 11
SFTPC surfactant protein C
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC16A4 solute carrier family 16, member 4
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC46A3 solute carrier family 46, member 3
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMS spermine synthase
SMYD2 SET and MYND domain containing 2
SORBS3 sorbin and SH3 domain containing 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
SQLE squalene epoxidase
SSR1 signal sequence receptor, alpha
SST somatostatin
STC1 stanniocalcin 1
STK39 serine threonine kinase 39
STS steroid sulfatase (microsomal), isozyme S
TBC1D16 TBC1 domain family, member 16
TBL1X transducin (beta)-like 1X-linked
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THBS2 thrombospondin 2
TKT transketolase
TMC5 transmembrane channel-like 5
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM109 transmembrane protein 109
TNS1 tensin 1
TPM2 tropomyosin 2 (beta)
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TUSC3 tumor suppressor candidate 3
TWF2 twinfilin actin binding protein 2
TXN thioredoxin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
URI1 URI1, prefoldin-like chaperone
VDAC1 voltage-dependent anion channel 1
VKORC1 vitamin K epoxide reductase complex, subunit 1
WNT5A wingless-type MMTV integration site family, member 5A
XPOT exportin, tRNA