BRD-A25687296_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

215 genes differentially expressed following the BRD-A25687296_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHR aryl hydrocarbon receptor
AMOTL2 angiomotin like 2
AOX1 aldehyde oxidase 1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARID4B AT rich interactive domain 4B (RBP1-like)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL3 B-cell CLL/lymphoma 3
BCL6 B-cell CLL/lymphoma 6
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C8ORF4 chromosome 8 open reading frame 4
CADM1 cell adhesion molecule 1
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCNL1 cyclin L1
CD9 CD9 molecule
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CGRRF1 cell growth regulator with ring finger domain 1
CHIC2 cysteine-rich hydrophobic domain 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLK4 CDC-like kinase 4
CLU clusterin
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL10A1 collagen, type X, alpha 1
CTGF connective tissue growth factor
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYLD cylindromatosis (turban tumor syndrome)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
CYTH1 cytohesin 1
DMTF1 cyclin D binding myb-like transcription factor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM129A family with sequence similarity 129, member A
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATAD1 GATA zinc finger domain containing 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IGFBP7 insulin-like growth factor binding protein 7
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL6 interleukin 6
ING3 inhibitor of growth family, member 3
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5B lysine (K)-specific demethylase 5B
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT5 keratin 5, type II
KYNU kynureninase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MCL1 myeloid cell leukemia 1
MGP matrix Gla protein
MSMB microseminoprotein, beta-
MTSS1 metastasis suppressor 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RHOB ras homolog family member B
RIPK2 receptor-interacting serine-threonine kinase 2
RND1 Rho family GTPase 1
RSRC2 arginine/serine-rich coiled-coil 2
SAMD4A sterile alpha motif domain containing 4A
SCYL3 SCY1-like 3 (S. cerevisiae)
SDC4 syndecan 4
SFTPB surfactant protein B
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC31A2 solute carrier family 31 (copper transporter), member 2
SOCS3 suppressor of cytokine signaling 3
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
SWAP70 SWAP switching B-cell complex 70kDa subunit
TACSTD2 tumor-associated calcium signal transducer 2
THBS1 thrombospondin 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TLK2 tousled-like kinase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
WSB1 WD repeat and SOCS box containing 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
B3GNT1
BCHE butyrylcholinesterase
CA12 carbonic anhydrase XII
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC92 coiled-coil domain containing 92
CCNG1 cyclin G1
CDC25A cell division cycle 25A
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP1 cysteine and glycine-rich protein 1
DBN1 drebrin 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ECI2 enoyl-CoA delta isomerase 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ENDOD1 endonuclease domain containing 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM57A family with sequence similarity 57, member A
FKBP9 FK506 binding protein 9, 63 kDa
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KAZN kazrin, periplakin interacting protein
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KIAA0100 KIAA0100
LBR lamin B receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKSL1 MARCKS-like 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLEC malectin
MNDA myeloid cell nuclear differentiation antigen
MPZL1 myelin protein zero-like 1
MTDH metadherin
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
OXTR oxytocin receptor
PDGFA platelet-derived growth factor alpha polypeptide
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PFN2 profilin 2
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
RNASET2 ribonuclease T2
RPS27L ribosomal protein S27-like
S100A12 S100 calcium binding protein A12
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPCS3 signal peptidase complex subunit 3 homolog (S. cerevisiae)
TBC1D4 TBC1 domain family, member 4
TMEM164 transmembrane protein 164
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TPD52L1 tumor protein D52-like 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
TUBB tubulin, beta class I
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WSB2 WD repeat and SOCS box containing 2