BRD-A25687296_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

216 genes differentially expressed following the BRD-A25687296_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADD3 adducin 3 (gamma)
ANKRD28 ankyrin repeat domain 28
ARHGAP29 Rho GTPase activating protein 29
ARID5B AT rich interactive domain 5B (MRF1-like)
ASUN asunder spermatogenesis regulator
ATF3 activating transcription factor 3
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BCL2A1 BCL2-related protein A1
BHLHE41 basic helix-loop-helix family, member e41
BIK BCL2-interacting killer (apoptosis-inducing)
C21ORF91 chromosome 21 open reading frame 91
C8ORF4 chromosome 8 open reading frame 4
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCNL1 cyclin L1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2AIP CDKN2A interacting protein
CHIC2 cysteine-rich hydrophobic domain 2
CLK4 CDC-like kinase 4
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EGR1 early growth response 1
EGR3 early growth response 3
ELF1 E74-like factor 1 (ets domain transcription factor)
ETNK1 ethanolamine kinase 1
FAM13A family with sequence similarity 13, member A
FAM179B family with sequence similarity 179, member B
FHL2 four and a half LIM domains 2
FNBP4 formin binding protein 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCC2 GRIP and coiled-coil domain containing 2
H1F0 H1 histone family, member 0
H2BFS H2B histone family, member S (pseudogene)
HAL histidine ammonia-lyase
HES1 hes family bHLH transcription factor 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AE histone cluster 1, H2ae
HIST1H2BD histone cluster 1, H2bd
HIST1H2BE histone cluster 1, H2be
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BH histone cluster 1, H2bh
HIST1H2BK histone cluster 1, H2bk
HIST1H4H histone cluster 1, H4h
IER2 immediate early response 2
IER3 immediate early response 3
IL6 interleukin 6
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KIAA0485 uncharacterized LOC57235
KIAA1033 KIAA1033
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
KRCC1 lysine-rich coiled-coil 1
KYNU kynureninase
LPXN leupaxin
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MTF2 metal response element binding transcription factor 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKTR natural killer cell triggering receptor
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PCBP2 poly(rC) binding protein 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSPC1 paraspeckle component 1
PTBP2 polypyrimidine tract binding protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RNMT RNA (guanine-7-) methyltransferase
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSRC2 arginine/serine-rich coiled-coil 2
SLC16A6 solute carrier family 16, member 6
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD3 SMAD family member 3
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SRSF7 serine/arginine-rich splicing factor 7
SYNE1 spectrin repeat containing, nuclear envelope 1
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TEX10 testis expressed 10
TGIF1 TGFB-induced factor homeobox 1
THUMPD2 THUMP domain containing 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae)
TSC22D1 TSC22 domain family, member 1
TUFT1 tuftelin 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
ZBTB20 zinc finger and BTB domain containing 20
ZFP36 ZFP36 ring finger protein
ZNF451 zinc finger protein 451
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AK4 adenylate kinase 4
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANXA4 annexin A4
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AUTS2 autism susceptibility candidate 2
B3GNT1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
C14ORF132 chromosome 14 open reading frame 132
C1QB complement component 1, q subcomponent, B chain
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CANT1 calcium activated nucleotidase 1
CAST calpastatin
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CCNF cyclin F
CD14 CD14 molecule
CD93 CD93 molecule
CD99 CD99 molecule
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL5A1 collagen, type V, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CX3CR1 chemokine (C-X3-C motif) receptor 1
DCHS1 dachsous cadherin-related 1
DES desmin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DPP4 dipeptidyl-peptidase 4
DPYSL2 dihydropyrimidinase-like 2
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FAM57A family with sequence similarity 57, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FHL1 four and a half LIM domains 1
FSTL1 follistatin-like 1
GAL galanin/GMAP prepropeptide
GLO1 glyoxalase I
GLUL glutamate-ammonia ligase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPC3 glypican 3
GPR161 G protein-coupled receptor 161
GRN granulin
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
KANK2 KN motif and ankyrin repeat domains 2
KAZN kazrin, periplakin interacting protein
KIAA0930 KIAA0930
KIF20A kinesin family member 20A
LAPTM4B lysosomal protein transmembrane 4 beta
LMNB2 lamin B2
MAOA monoamine oxidase A
MAP1B microtubule-associated protein 1B
MEIS2 Meis homeobox 2
MEX3D mex-3 RNA binding family member D
MLEC malectin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MUC4 mucin 4, cell surface associated
NES nestin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
PBX3 pre-B-cell leukemia homeobox 3
PSAT1 phosphoserine aminotransferase 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RBP1 retinol binding protein 1, cellular
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASE6 ribonuclease, RNase A family, k6
RTN1 reticulon 1
RXRA retinoid X receptor, alpha
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX6 sorting nexin 6
SNX7 sorting nexin 7
SORBS1 sorbin and SH3 domain containing 1
TMSB15A thymosin beta 15a
TUBB tubulin, beta class I
TYROBP TYRO protein tyrosine kinase binding protein
VASH1 vasohibin 1
XCL1 chemokine (C motif) ligand 1