BRD-A25416824_NRB 03823_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

86 genes differentially expressed following the BRD-A25416824_NRB 03823_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA3 annexin A3
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BIK BCL2-interacting killer (apoptosis-inducing)
BTG3 BTG family, member 3
C1S complement component 1, s subcomponent
CALD1 caldesmon 1
CD47 CD47 molecule
CFB complement factor B
CFI complement factor I
CSK c-src tyrosine kinase
CSRP2 cysteine and glycine-rich protein 2
CTSB cathepsin B
CTTN cortactin
DLG5 discs, large homolog 5 (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FKBP5 FK506 binding protein 5
FOXO3 forkhead box O3
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLRX glutaredoxin (thioltransferase)
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
IFI27 interferon, alpha-inducible protein 27
IGF1R insulin-like growth factor 1 receptor
IGFBP6 insulin-like growth factor binding protein 6
IL6ST interleukin 6 signal transducer
INPP1 inositol polyphosphate-1-phosphatase
IRS2 insulin receptor substrate 2
KIF14 kinesin family member 14
KRT19 keratin 19, type I
LGMN legumain
MAB21L1 mab-21-like 1 (C. elegans)
MAPK6 mitogen-activated protein kinase 6
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCL1 myeloid cell leukemia 1
MPZL1 myelin protein zero-like 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
PALLD palladin, cytoskeletal associated protein
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SESN1 sestrin 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SYBU syntabulin (syntaxin-interacting)
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZBTB16 zinc finger and BTB domain containing 16
ZBTB20 zinc finger and BTB domain containing 20

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CCDC85B coiled-coil domain containing 85B
COL1A2 collagen, type I, alpha 2
COL5A1 collagen, type V, alpha 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
GATA6 GATA binding protein 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HOPX HOP homeobox
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
INSIG1 insulin induced gene 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAMA4 laminin, alpha 4
LAMP5 lysosomal-associated membrane protein family, member 5
MGP matrix Gla protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM1 neural cell adhesion molecule 1
NPIPB3 nuclear pore complex interacting protein family, member B3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PPT1 palmitoyl-protein thioesterase 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
TMEM97 transmembrane protein 97
TRIB1 tribbles pseudokinase 1
TSPAN12 tetraspanin 12