BRD-A25337146_-666_PC3_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-A25337146_-666_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA2 acetyl-CoA acyltransferase 2
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
CD24 CD24 molecule
CD52 CD52 molecule
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
FAM69A family with sequence similarity 69, member A
HK2 hexokinase 2
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
JUN jun proto-oncogene
MTUS1 microtubule associated tumor suppressor 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NQO1 NAD(P)H dehydrogenase, quinone 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
RGS10 regulator of G-protein signaling 10
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
APOD apolipoprotein D
ASPH aspartate beta-hydroxylase
AXL AXL receptor tyrosine kinase
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
CCNA2 cyclin A2
CCNF cyclin F
CHIC2 cysteine-rich hydrophobic domain 2
CHRDL1 chordin-like 1
DUSP10 dual specificity phosphatase 10
F3 coagulation factor III (thromboplastin, tissue factor)
G0S2 G0/G1 switch 2
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
HNRNPL heterogeneous nuclear ribonucleoprotein L
IL1B interleukin 1, beta
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
KRT7 keratin 7, type II
LAMC2 laminin, gamma 2
LCN2 lipocalin 2
LDHB lactate dehydrogenase B
MXRA5 matrix-remodelling associated 5
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PIP prolactin-induced protein
PLAT plasminogen activator, tissue
PLAUR plasminogen activator, urokinase receptor
PLIN1 perilipin 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCGB2A2 secretoglobin, family 2A, member 2
SFRP1 secreted frizzled-related protein 1
TGM2 transglutaminase 2
TLR4 toll-like receptor 4
TUBB4B tubulin, beta 4B class IVb