BRD-A25337146_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

148 genes differentially expressed following the BRD-A25337146_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ASS1 argininosuccinate synthase 1
BTG2 BTG family, member 2
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC5A C-type lectin domain family 5, member A
COL15A1 collagen, type XV, alpha 1
COL4A5 collagen, type IV, alpha 5
COL6A2 collagen, type VI, alpha 2
CTSK cathepsin K
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DEFA4 defensin, alpha 4, corticostatin
EGLN3 egl-9 family hypoxia-inducible factor 3
EML3 echinoderm microtubule associated protein like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EYA2 EYA transcriptional coactivator and phosphatase 2
FAM129A family with sequence similarity 129, member A
FASTKD5 FAST kinase domains 5
FXYD5 FXYD domain containing ion transport regulator 5
GAGE3 G antigen 3
GCG glucagon
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPNMB glycoprotein (transmembrane) nmb
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IPO13 importin 13
JAG1 jagged 1
LCN2 lipocalin 2
LGALS2 lectin, galactoside-binding, soluble, 2
LINC00341 long intergenic non-protein coding RNA 341
LOC100505650 uncharacterized LOC100505650
LTB lymphotoxin beta (TNF superfamily, member 3)
MAGEA3 melanoma antigen family A3
MMP9 matrix metallopeptidase 9
NVL nuclear VCP-like
PCDH7 protocadherin 7
PDZK1IP1 PDZK1 interacting protein 1
PERP PERP, TP53 apoptosis effector
PKP2 plakophilin 2
PRKCQ protein kinase C, theta
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS16 regulator of G-protein signaling 16
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A1 secretoglobin, family 2A, member 1
SCPEP1 serine carboxypeptidase 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPP1 secreted phosphoprotein 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STC1 stanniocalcin 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TCEA2 transcription elongation factor A (SII), 2
TGFB1 transforming growth factor, beta 1
TRAF3IP2 TRAF3 interacting protein 2
TRD T cell receptor delta locus
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT2 acetyl-CoA acetyltransferase 2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ANXA6 annexin A6
ARHGAP29 Rho GTPase activating protein 29
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
BEX1 brain expressed, X-linked 1
CD81 CD81 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK7 cyclin-dependent kinase 7
CELF2 CUGBP, Elav-like family member 2
CHSY1 chondroitin sulfate synthase 1
CORO1C coronin, actin binding protein, 1C
COTL1 coactosin-like F-actin binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRP1 cysteine and glycine-rich protein 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DACH1 dachshund family transcription factor 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DHCR24 24-dehydrocholesterol reductase
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF5 eukaryotic translation initiation factor 5
ETV1 ets variant 1
FABP7 fatty acid binding protein 7, brain
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FSCN1 fascin actin-bundling protein 1
FSTL1 follistatin-like 1
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GPX1 glutathione peroxidase 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HN1 hematological and neurological expressed 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM2 interferon induced transmembrane protein 2
IGFBP4 insulin-like growth factor binding protein 4
KPNB1 karyopherin (importin) beta 1
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LY6E lymphocyte antigen 6 complex, locus E
MAGED2 melanoma antigen family D2
MARCKS myristoylated alanine-rich protein kinase C substrate
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NEFH neurofilament, heavy polypeptide
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
OPN3 opsin 3
PALLD palladin, cytoskeletal associated protein
PGRMC1 progesterone receptor membrane component 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RER1 retention in endoplasmic reticulum sorting receptor 1
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCRN1 secernin 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SPINT2 serine peptidase inhibitor, Kunitz type, 2
TBL1X transducin (beta)-like 1X-linked
TMEM100 transmembrane protein 100
TUBB tubulin, beta class I
VCAN versican
WSB1 WD repeat and SOCS box containing 1