BRD-A25337146_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-A25337146_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
BAG3 BCL2-associated athanogene 3
BPHL biphenyl hydrolase-like (serine hydrolase)
CBR3 carbonyl reductase 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
CTSL cathepsin L
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FOSL1 FOS-like antigen 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6R interleukin 6 receptor
JMJD6 jumonji domain containing 6
JUN jun proto-oncogene
LAPTM4B lysosomal protein transmembrane 4 beta
LST1 leukocyte specific transcript 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1F metallothionein 1F
MT1X metallothionein 1X
MYC v-myc avian myelocytomatosis viral oncogene homolog
NQO1 NAD(P)H dehydrogenase, quinone 1
PRNP prion protein
PTX3 pentraxin 3, long
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TRIM16 tripartite motif containing 16
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ANOS1 anosmin 1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASCL1 achaete-scute family bHLH transcription factor 1
B3GNT1
BEX1 brain expressed, X-linked 1
CHN2 chimerin 2
CHRDL1 chordin-like 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM13A family with sequence similarity 13, member A
FHL1 four and a half LIM domains 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
METTL7A methyltransferase like 7A
NDN necdin, melanoma antigen (MAGE) family member
NFIB nuclear factor I/B
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NUAK1 NUAK family, SNF1-like kinase, 1
PDE1A phosphodiesterase 1A, calmodulin-dependent
PPARG peroxisome proliferator-activated receptor gamma
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PURA purine-rich element binding protein A
QPCT glutaminyl-peptide cyclotransferase
REG1A regenerating islet-derived 1 alpha
REG3A regenerating islet-derived 3 alpha
RGS13 regulator of G-protein signaling 13
RGS2 regulator of G-protein signaling 2
SALL2 spalt-like transcription factor 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SWAP70 SWAP switching B-cell complex 70kDa subunit
TCF4 transcription factor 4
TFF1 trefoil factor 1
TNIK TRAF2 and NCK interacting kinase
TSPAN13 tetraspanin 13
VCAN versican