BRD-A25337146_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-A25337146_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP3 aquaporin 3 (Gill blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BCL6 B-cell CLL/lymphoma 6
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD24 CD24 molecule
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CSRP1 cysteine and glycine-rich protein 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
FOSL1 FOS-like antigen 1
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
HCAR3 hydroxycarboxylic acid receptor 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IFRD1 interferon-related developmental regulator 1
IGF1R insulin-like growth factor 1 receptor
INHBE inhibin, beta E
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
KYNU kynureninase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MBNL2 muscleblind-like splicing regulator 2
MMP7 matrix metallopeptidase 7
MTCL1 microtubule crosslinking factor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SH3BP4 SH3-domain binding protein 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPD52 tumor protein D52
TTN titin
TXNL4B thioredoxin-like 4B
USP6NL USP6 N-terminal like
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ADD3 adducin 3 (gamma)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AURKA aurora kinase A
CCNF cyclin F
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COX11 COX11 cytochrome c oxidase copper chaperone
ESR1 estrogen receptor 1
FABP4 fatty acid binding protein 4, adipocyte
FAM98A family with sequence similarity 98, member A
FBN1 fibrillin 1
FGB fibrinogen beta chain
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GJA1 gap junction protein, alpha 1, 43kDa
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAP3 leucine aminopeptidase 3
LPL lipoprotein lipase
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MMP9 matrix metallopeptidase 9
NID2 nidogen 2 (osteonidogen)
PCP4 Purkinje cell protein 4
PDGFRL platelet-derived growth factor receptor-like
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPIF peptidylprolyl isomerase F
SEC23A Sec23 homolog A (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
THAP11 THAP domain containing 11
TUBB6 tubulin, beta 6 class V
UBE2C ubiquitin-conjugating enzyme E2C
WRB tryptophan rich basic protein