BRD-A25337146_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

97 genes differentially expressed following the BRD-A25337146_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
APOD apolipoprotein D
ASPN asporin
BAG3 BCL2-associated athanogene 3
CCL5 chemokine (C-C motif) ligand 5
CD14 CD14 molecule
CD163 CD163 molecule
CES1 carboxylesterase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLTC clathrin, heavy chain (Hc)
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A2 collagen, type VI, alpha 2
CSRP1 cysteine and glycine-rich protein 1
DAAM2 dishevelled associated activator of morphogenesis 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EFHD1 EF-hand domain family, member D1
GALC galactosylceramidase
GATA3 GATA binding protein 3
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
HMOX1 heme oxygenase 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
KRT16 keratin 16, type I
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP11 matrix metallopeptidase 11
MMP14 matrix metallopeptidase 14 (membrane-inserted)
NOTCH3 notch 3
NR0B1 nuclear receptor subfamily 0, group B, member 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PIR pirin (iron-binding nuclear protein)
PLAU plasminogen activator, urokinase
PMP22 peripheral myelin protein 22
PTK2 protein tyrosine kinase 2
PTPRK protein tyrosine phosphatase, receptor type, K
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS20 regulator of G-protein signaling 20
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
STAB1 stabilin 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AKIRIN1 akirin 1
ANXA3 annexin A3
BAMBI BMP and activin membrane-bound inhibitor
CCND2 cyclin D2
CCNG2 cyclin G2
CD59 CD59 molecule, complement regulatory protein
CFI complement factor I
COASY CoA synthase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CYB561 cytochrome b561
DCK deoxycytidine kinase
EPN2 epsin 2
FAM63A family with sequence similarity 63, member A
G0S2 G0/G1 switch 2
GPX1 glutathione peroxidase 1
HES1 hes family bHLH transcription factor 1
LTF lactotransferrin
LYPLA1 lysophospholipase I
LYZ lysozyme
MARCKS myristoylated alanine-rich protein kinase C substrate
MGLL monoglyceride lipase
OXTR oxytocin receptor
PLAGL1 pleiomorphic adenoma gene-like 1
PLK1 polo-like kinase 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS11 ribosomal protein S11
SRPX sushi-repeat containing protein, X-linked
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
ZNF586 zinc finger protein 586