BRD-A25337146_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A25337146_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADCY9 adenylate cyclase 9
ANGPTL2 angiopoietin-like 2
APOA1 apolipoprotein A-I
ASPN asporin
ATP11B ATPase, class VI, type 11B
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCAM basal cell adhesion molecule (Lutheran blood group)
BCHE butyrylcholinesterase
BMP4 bone morphogenetic protein 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCND2 cyclin D2
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDK14 cyclin-dependent kinase 14
CEP57 centrosomal protein 57kDa
CES1 carboxylesterase 1
CFB complement factor B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COMP cartilage oligomeric matrix protein
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSK cathepsin K
EFHD1 EF-hand domain family, member D1
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FILIP1L filamin A interacting protein 1-like
FNDC3B fibronectin type III domain containing 3B
GAGE3 G antigen 3
GAS6 growth arrest-specific 6
GLUL glutamate-ammonia ligase
HDAC9 histone deacetylase 9
HLA-B major histocompatibility complex, class I, B
HMGN4 high mobility group nucleosomal binding domain 4
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPB3 heat shock 27kDa protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IPO13 importin 13
IQGAP1 IQ motif containing GTPase activating protein 1
JUP junction plakoglobin
KLHDC3 kelch domain containing 3
KRT19 keratin 19, type I
LINC00341 long intergenic non-protein coding RNA 341
MKNK1 MAP kinase interacting serine/threonine kinase 1
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
OBSL1 obscurin-like 1
PAM peptidylglycine alpha-amidating monooxygenase
PBX3 pre-B-cell leukemia homeobox 3
PDLIM3 PDZ and LIM domain 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLXNB2 plexin B2
PRKCI protein kinase C, iota
PTGIS prostaglandin I2 (prostacyclin) synthase
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RGS16 regulator of G-protein signaling 16
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
STON1 stonin 1
SULF1 sulfatase 1
TF transferrin
THBS2 thrombospondin 2
TRIM2 tripartite motif containing 2
VAMP8 vesicle-associated membrane protein 8
VGLL1 vestigial-like family member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACLY ATP citrate lyase
AHNAK2 AHNAK nucleoprotein 2
AKAP7 A kinase (PRKA) anchor protein 7
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDOA aldolase A, fructose-bisphosphate
AMD1 adenosylmethionine decarboxylase 1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANXA5 annexin A5
ARL4A ADP-ribosylation factor-like 4A
BEX1 brain expressed, X-linked 1
BTBD3 BTB (POZ) domain containing 3
CA12 carbonic anhydrase XII
CAPNS1 calpain, small subunit 1
CCDC86 coiled-coil domain containing 86
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CLU clusterin
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL5 chemokine (C-X-C motif) ligand 5
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
EBP emopamil binding protein (sterol isomerase)
ECI2 enoyl-CoA delta isomerase 2
ENO1 enolase 1, (alpha)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GAL galanin/GMAP prepropeptide
GPI glucose-6-phosphate isomerase
GSTP1 glutathione S-transferase pi 1
HN1 hematological and neurological expressed 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITM2A integral membrane protein 2A
KLF4 Kruppel-like factor 4 (gut)
KRT10 keratin 10, type I
LPAR1 lysophosphatidic acid receptor 1
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MALL mal, T-cell differentiation protein-like
MEOX2 mesenchyme homeobox 2
MET MET proto-oncogene, receptor tyrosine kinase
MSX1 msh homeobox 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
OXA1L oxidase (cytochrome c) assembly 1-like
PDLIM4 PDZ and LIM domain 4
PDZD8 PDZ domain containing 8
PEBP1 phosphatidylethanolamine binding protein 1
PEPD peptidase D
PFKP phosphofructokinase, platelet
PHB prohibitin
PHGDH phosphoglycerate dehydrogenase
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PLK1 polo-like kinase 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPIF peptidylprolyl isomerase F
PSENEN presenilin enhancer gamma secretase subunit
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSPH phosphoserine phosphatase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QDPR quinoid dihydropteridine reductase
RBM42 RNA binding motif protein 42
RGS2 regulator of G-protein signaling 2
RPL36 ribosomal protein L36
RPL39L ribosomal protein L39-like
SECISBP2L SECIS binding protein 2-like
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLIRP SRA stem-loop interacting RNA binding protein
SORD sorbitol dehydrogenase
SPRY2 sprouty homolog 2 (Drosophila)
SRM spermidine synthase
TBCB tubulin folding cofactor B
TESC tescalcin
TMEM147 transmembrane protein 147
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TXNL4A thioredoxin-like 4A
UBE2S ubiquitin-conjugating enzyme E2S
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZNF146 zinc finger protein 146