BRD-A25337146_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-A25337146_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADM adrenomedullin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID5B AT rich interactive domain 5B (MRF1-like)
ATF3 activating transcription factor 3
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BHLHE40 basic helix-loop-helix family, member e40
C10ORF10 chromosome 10 open reading frame 10
CACYBP calcyclin binding protein
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHI3L2 chitinase 3-like 2
CHIC2 cysteine-rich hydrophobic domain 2
CLIC4 chloride intracellular channel 4
COBL cordon-bleu WH2 repeat protein
CRYAB crystallin, alpha B
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM134B family with sequence similarity 134, member B
FAM57A family with sequence similarity 57, member A
FHL2 four and a half LIM domains 2
FOSL2 FOS-like antigen 2
FRY furry homolog (Drosophila)
GAB2 GRB2-associated binding protein 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GDF15 growth differentiation factor 15
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IL32 interleukin 32
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM3A lysine (K)-specific demethylase 3A
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MMP1 matrix metallopeptidase 1
MSX1 msh homeobox 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9
OPN3 opsin 3
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PELI1 pellino E3 ubiquitin protein ligase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTPRM protein tyrosine phosphatase, receptor type, M
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SH3YL1 SH3 and SYLF domain containing 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SOCS3 suppressor of cytokine signaling 3
SOD2 superoxide dismutase 2, mitochondrial
SPP1 secreted phosphoprotein 1
SPRED2 sprouty-related, EVH1 domain containing 2
TFF3 trefoil factor 3 (intestinal)
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
TUFT1 tuftelin 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
ALOX5 arachidonate 5-lipoxygenase
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AURKA aurora kinase A
CAV1 caveolin 1, caveolae protein, 22kDa
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNF cyclin F
CFI complement factor I
COASY CoA synthase
COL13A1 collagen, type XIII, alpha 1
COL1A2 collagen, type I, alpha 2
CXCL9 chemokine (C-X-C motif) ligand 9
DPYSL3 dihydropyrimidinase-like 3
ERAP2 endoplasmic reticulum aminopeptidase 2
EVI2B ecotropic viral integration site 2B
FLRT2 fibronectin leucine rich transmembrane protein 2
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KIF18B kinesin family member 18B
LYPD1 LY6/PLAUR domain containing 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MDK midkine (neurite growth-promoting factor 2)
NT5DC2 5'-nucleotidase domain containing 2
NUSAP1 nucleolar and spindle associated protein 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYGB phosphorylase, glycogen; brain
RBM3 RNA binding motif (RNP1, RRM) protein 3
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFPI2 tissue factor pathway inhibitor 2
TOP2A topoisomerase (DNA) II alpha 170kDa
VDAC1 voltage-dependent anion channel 1