BRD-A25234499_aminoglutethimide_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

94 genes differentially expressed following the BRD-A25234499_aminoglutethimide_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
BLNK B-cell linker
CD44 CD44 molecule (Indian blood group)
CD9 CD9 molecule
CDK14 cyclin-dependent kinase 14
CFB complement factor B
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DENND1B DENN/MADD domain containing 1B
EHD3 EH-domain containing 3
EPAS1 endothelial PAS domain protein 1
FBXL12 F-box and leucine-rich repeat protein 12
FZD6 frizzled class receptor 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP5 insulin-like growth factor binding protein 5
IPO13 importin 13
IRS1 insulin receptor substrate 1
ITM2C integral membrane protein 2C
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KRT15 keratin 15, type I
KYNU kynureninase
LGALS3 lectin, galactoside-binding, soluble, 3
LMO2 LIM domain only 2 (rhombotin-like 1)
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MME membrane metallo-endopeptidase
MPPED2 metallophosphoesterase domain containing 2
MPZL2 myelin protein zero-like 2
MTSS1 metastasis suppressor 1
NT5E 5'-nucleotidase, ecto (CD73)
ORC1 origin recognition complex, subunit 1
P3H2 prolyl 3-hydroxylase 2
PEA15 phosphoprotein enriched in astrocytes 15
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PTPRK protein tyrosine phosphatase, receptor type, K
RGCC regulator of cell cycle
RNF24 ring finger protein 24
S100A8 S100 calcium binding protein A8
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SNX13 sorting nexin 13
TRIM2 tripartite motif containing 2
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
AK1 adenylate kinase 1
ANXA6 annexin A6
C1QTNF3 C1q and tumor necrosis factor related protein 3
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CDKN2A cyclin-dependent kinase inhibitor 2A
CELF2 CUGBP, Elav-like family member 2
CHRDL1 chordin-like 1
COMP cartilage oligomeric matrix protein
CRIP1 cysteine-rich protein 1 (intestinal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FAM46A family with sequence similarity 46, member A
FBLN5 fibulin 5
FBXO11 F-box protein 11
FKBP10 FK506 binding protein 10, 65 kDa
FOLR1 folate receptor 1 (adult)
GSTM3 glutathione S-transferase mu 3 (brain)
HSPB8 heat shock 22kDa protein 8
IGKC immunoglobulin kappa constant
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
KIAA0125 KIAA0125
LAPTM4B lysosomal protein transmembrane 4 beta
MFAP5 microfibrillar associated protein 5
MFSD10 major facilitator superfamily domain containing 10
MSRB2 methionine sulfoxide reductase B2
NNMT nicotinamide N-methyltransferase
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
QDPR quinoid dihydropteridine reductase
REG3A regenerating islet-derived 3 alpha
RPS11 ribosomal protein S11
S100B S100 calcium binding protein B
SELENBP1 selenium binding protein 1
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN4 tetraspanin 4