BRD-A25234499_aminoglutethimide_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-A25234499_aminoglutethimide_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTN1 actinin, alpha 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CDC14B cell division cycle 14B
CHL1 cell adhesion molecule L1-like
CHPT1 choline phosphotransferase 1
CLIC4 chloride intracellular channel 4
CRIP1 cysteine-rich protein 1 (intestinal)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL6ST interleukin 6 signal transducer
JMJD6 jumonji domain containing 6
LTF lactotransferrin
MARCKSL1 MARCKS-like 1
METRN meteorin, glial cell differentiation regulator
MFAP3L microfibrillar-associated protein 3-like
MSX1 msh homeobox 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NPY neuropeptide Y
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3YL1 SH3 and SYLF domain containing 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
TBXA2R thromboxane A2 receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TIAM1 T-cell lymphoma invasion and metastasis 1
TJP2 tight junction protein 2
TNC tenascin C
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AURKB aurora kinase B
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
CCND2 cyclin D2
CD24 CD24 molecule
CD93 CD93 molecule
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CORO1A coronin, actin binding protein, 1A
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DENND1B DENN/MADD domain containing 1B
EDNRA endothelin receptor type A
ERBB4 erb-b2 receptor tyrosine kinase 4
FBN2 fibrillin 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEATR1 HEAT repeat containing 1
IGF1 insulin-like growth factor 1 (somatomedin C)
LAMP3 lysosomal-associated membrane protein 3
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
MFAP2 microfibrillar-associated protein 2
MMP2 matrix metallopeptidase 2
NCF2 neutrophil cytosolic factor 2
NEB nebulin
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PTN pleiotrophin
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SFRP1 secreted frizzled-related protein 1
SOX11 SRY (sex determining region Y)-box 11
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNC1 troponin C type 1 (slow)
VCAN versican